Rivista di formazione e aggiornamento professionale del pediatra e del medico di base, fondata nel 1982. In collaborazione con l'Associazione Culturale Pediatri.
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Percorsi clinici

Trombosi venosa cerebrale associata a otomastoidite con segni di ipertensione endocranica

Cerebral venous thrombosis associated with otomastoiditis and endocranial hypertension

Angela Troisi1, Elisa Pasquali1,2, Alessandra Iacono1, Carlotta Farneti1, Enrico Cocchi1,3, Ignacio Javier Fernandez3,4, Chiara Romeo5, Federico Marchetti1,3

1UOC di Pediatria e Neonatologica, Ospedale di Ravenna, AUSL della Romagna
2Scuola di Specializzazione in Pediatria, Università di Bologna
3Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Università di Bologna
4UOC di Otorinolaringoiatria, 5SSD di Neuroradiologia, Ospedale di Ravenna, AUSL della Romagna

Gennaio 2025 - pagg. 25 -31 | DOI: 10.53126/MEB44025

Abstract
Venous thrombosis of the cerebral sinuses can complicate acute otitis media (AOM) due to the close anatomical relationship between these structures. This condition presents a diagnostic challenge for clinicians, as it often manifests with nonspecific symptoms like headaches and carries the risk of quickly developing into intracranial hypertension. The paper presents the case of a 10-year-old child with a history of AOM who developed headache, later diagnosed as otomastoiditis complicated by thrombosis of the sigmoid sinus and jugular-sigmoid junction. The patient required surgical intervention, along with antibiotic and anticoagulant therapy, leading to a full resolution of the thrombosis.
Riassunto
La trombosi venosa dei seni cerebrali è una possibile complicanza dell’otite media acuta (OMA), derivante dalla prossimità anatomica delle strutture coinvolte. Questa rappresenta un’insidia per il clinico vista la presentazione sfumata con una generica cefalea, associata al rischio di rapida degenerazione in ipertensione endocranica. Riportiamo il caso di un bambino di dieci anni giunto alla nostra attenzione per cefalea e pregressa otite come presentazione di una otomastoidite complicata da trombosi seno sigmoide e del passaggio giugulare-sigmoideo, che ha richiesto trattamento chirurgico, oltre alla terapia farmacologica antibiotica e anticoagulante, con completa risoluzione della trombosi.
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Bibliografia
1. Sarno LD, Cammisa I, Curatola A, et al. A scoping review of the management of acute mastoiditis in children: What is the best approach? Turk J Pediatr 2023;65(6):906-18. doi: 10.24953/turkjped.2023.320. 2. Häußler SM, Peichl J, Bauknecht C, et al. A Novel Diagnostic and Treatment Algorithm for Acute Mastoiditis in Children Based on 109 Cases. Otol Neurotol 2024;45(3): e241-e247. doi: 10.1097/MAO.000000000000 4089. 3. Cassano P, Ciprandi G, Passali D. Acute mastoiditis in children. Acta Biomed 2020;91 (1-S):54-9. doi: 10.23750/abm. v91i1-S.9259. 4. Psarommatis IM, Voudouris C, Douros K, Giannakopoulos P, Bairamis T, Carabinos C. Algorithmic management of pediatric acute mastoiditis. Int J Pediatr Otorhinolaryngol 2012;76(6):791-6. doi: 10.1016/j.ijporl.2012. 02.042. 5. Wald ER. Acute mastoiditis in children: Clinical features and diagnosis. Literature review current through: Jun 2024. UpToDate May 10, 2023. 6. Goldberg-Bockhorn E, Hurzlmeier C, Vahl JM, et al. Increase in acute mastoiditis at the end of the COVID-19 pandemic. Eur Arch Otorhinolaryngol 2024281(9):4747-56. doi: 10.1007/s00405-024-08704-y. 7. Samuel O, Saliba W, Stein N, Shiner Y, Cohen-Kerem R. Emerging Clinical Features of Acute Mastoiditis in Israel: A Registry Based Cohort. Pediatr Infect Dis J 2024;43(7): 620-5. doi: 10.1097/INF.000000000000 4325. 8. Manolidis S, Kutz JW Jr. Diagnosis and management of lateral sinus thrombosis. Otol Neurotol 2005;26(5):1045-51. doi: 10. 1097/01.mao.0000170536.49646.ec. 9. Zanoletti E, Cazzador D, Faccioli C, Sari M, Bovo R, Martini A. Intracranial venous sinus thrombosis as a complication of otitis media in children: critical review of diagnosis and management. Int J Pediatr Otorhinolaryngol 2015;79(12):2398-403. doi: 10.1016/ j.ijporl.2015.10.059. 10. Wong BY, Hickman S, Richards M, Jassar P, Wilson T. Management of paediatric otogenic cerebral venous sinus thrombosis: a systematic review. Clin Otolaryngol 2015;40 (6):704-14. doi: 10.1111/coa.12504. 11. Castellazzi ML, di Pietro GM, Gaffuri M, et al. Pediatric otogenic cerebral venous sinus thrombosis: a case report and a literature review. Ital J Pediatr 2020;46(1):122. doi: 10.1186/s13052-020-00882-9. 12. Ulanovski D, Yacobovich J, Kornreich L, Shkalim V, Raveh E. Pediatric otogenic sigmoid sinus thrombosis: 12-Year experience. Int J Pediatr Otorhinolaryngol 2014;78(6): 930-3. doi: 10.1016/j.ijporl.2014.03.016. 13. Chalmers E, Ganesen V, Liesner R, et al.; British Committee for Standards in Haematology. Guideline on the investigation, management and prevention of venous thrombosis in children. Br J Haematol 2011;154(2):196-207. doi: 10.1111/j.1365-2141.2010.08543.x. 14. Wald ER. Acute mastoiditis in children: Treatment and prevention Literature review current through: Jun 2024. This topic last updated: May 05, 2023. 15. Quesnel S, Nguyen M, Pierrot S, Contencin P, Manach Y, Couloigner V. Acute mastoiditis in children: a retrospective study of 188 patients. Int J Pediatr Otorhinolaryngol 2010;74(12):1388-92. doi: 10.1016/j.ijporl. 2010.09.013. 16. Monagle P, Chan AKC, Goldenberg NA, et al. Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141 (2 Suppl):e737S-e801S. doi: 10.1378/chest. 11-2308. 17. Novoa E, Podvinec M, Angst R, Gürtler N. Paediatric otogenic lateral sinus thrombosis: therapeutic management, outcome and thrombophilic evaluation. Int J Pediatr Otorhinolaryngol 2013;77(6):996-1001. doi: 10.1016/j.ijporl.2013.03.030. 18. Vergadi E, Velegrakis S, Raissaki M, Bitsori M, Karatzanis A, Galanakis E. Acute mastoiditis complicated by cerebral venous sinus thrombosis in children. Int J Pediatr Otorhinolaryngol 2021;141:110508. doi: 10.1016/j.ijporl.2020.110508. 19. Parodi E, Del Borrello G, Portulano C, Saracco P, Ramenghi U. La trombosi venosa nel bambino. Medico e Bambino 2021;40(2): 103-8. doi: 10.53126/MEB40103. 20. Male C, Lensing AWA, Palumbo JS, et al; EINSTEIN-Jr Phase 3 Investigators. Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial. Lancet Haematol 2020;7(1):e18-e27. doi: 10.1016/S2352-3026 (19)30219-4. 21. Young G, Lensing AWA, Monagle P, et al; EINSTEIN-Jr. Phase 3 Investigators. Rivaroxaban for treatment of pediatric venous thromboembolism. An Einstein-Jr phase 3 dose-exposure-response evaluation. J Thromb Haemost 2020;18(7):1672-85. doi: 10.1111/ jth.14813. 22. https://medicinali.aifa.gov.it/it/#/it/organizzazione/689/farmaci/38744/stampati/FI. 23. Connor P, Sánchez van Kammen M, Lensing AWA, et al. Safety and efficacy of rivaroxa-ban in pediatric cerebral venous thrombosis (EINSTEIN-Jr CVT). Blood Adv 2020;4 (24):6250-8. doi: 10.1182/bloodadvances. 2020003244. 24. Schneider S, Kapelushnik J, Kraus M, El Saied S, Levi I, Kaplan DM. The association be-tween otogenic lateral sinus thrombosis and thrombophilia - A long-term follow-up. Am J Otolaryngol 2018;39(3):299-302. doi: 10.1016/j.amjoto.2018.03.013. 25. Kenet G, Kirkham F, Niederstadt T, et al.; European Thromboses Study Group. Risk factors for recurrent venous thromboembolism in the European collaborative paediatric database on cerebral venous thrombosis: a multicentre cohort study. Lancet Neurol 2007;6(7):595-603. doi: 10.1016/S1474-4422 (07)70131-X. 26. Bartolozzi G. Trombosi delle vene e dei seni cerebrali (Parte seconda). Medico e Bambino pagine elettroniche 2006;9(4). 27. Cleves-Bayon C. Idiopathic Intracranial Hypertension in Children and Adolescents: An Up-date. Headache 2018;58(3):485-93. doi: 10.1111/head.13236. 28. Aylward SC, Way AL. Pediatric Intracranial Hypertension: a Current Literature Review. Curr Pain Headache Rep 2018;22(2):14. doi: 10.1007/s11916-018-0665-9. 29. Michael Wall, MD, Andrew G Lee, MD. Idiopathic intracranial hypertension (pseudotumor cerebri): Prognosis and treatment. Literature review current through: Jun 2024. This topic last Uptodate: Apr 01, 2024. 30. Medici A, Falcini M, Barni S, et al. Ipertensione endocranica idiopatica in un ragazzo con obesità. Medico e Bambino pagine elettroniche 2011;14(6). 31. Ghosh PS, Ghosh D, Goldfarb J, Sabella C. Lateral sinus thrombosis associated with mastoiditis and otitis media in children: a retrospective chart review and review of the literature. J Child Neurol 2011;26(8):1000-4. doi: 10.1177/0883073811401745. 32. Sandrin C, Favret A, Magnolato A. Trombosi dei seni venosi associata a mastoidite e otite media acuta. Medico e Bambino pagine elettroniche 2014;17(1). 33. Marchetti F, Barbi E. Antibiotici. Medico e Bambino 2021;40(26):2 doi: 10.53126/ MEB40S701. 34. Consensus Intersocietaria. Impiego giudizioso della terapia antibiotica nelle infezioni delle vie aeree in età evolutiva. Pediatria Preventiva & Sociale. Supplemento al numero 3 - 2023. 35. Draut S, Müller J, Hempel JM, Schrötzlmair F, Simon F. Tenfold Increase: Acute Pediatric Mastoiditis Before, During, and After COVID-19 Restrictions. Otol Neurotol 2024;45(7):777-82. doi: 10.1097/MAO. 0000000000004238. 36. Di Mario S, Gagliotti C, Buttazzi R, Marchetti F, Dodi I, Barbieri L, Moro ML. Reducing antibiotic prescriptions in children is not associated with higher rate of complications. Eur J Pediatr 2021;180(4):1185-92. doi: 10.1007/s00431-020-03861-8. 37. Nygaard U, Hartling UB, Munkstrup C, et al. Invasive group A streptococcal infections in children and adolescents in Denmark during 2022-23 compared with 2016-17 to 2021-22: a nationwide, multicentre, population-based cohort study. Lancet Child Adolesc Health 2024;8(2):112-21. doi: 10.1016/S2352-4642(23)00295-X. 38. Marchetti F. Uso degli antibiotici in età pediatrica: riflessioni e azioni. Medico e Bambino 2024;43(7):450-7. doi: 10.53126/ MEB43450.

Corrispondenza: angela.troisi@auslromagna.it