Aggiornamento monografico
La diagnosi di ittero colestatico nel neonato
DIAGNOSIS OF CHOLESTATIC JAUNDICE IN THE NEWBORN BABY
GIUSEPPE MAGGIORE, SILVIA CAPRAI
Dipartimento di Medicina della Procreazione e dell’Età Evolutiva, Università degli Studi di Pisa
Marzo 1999 - pagg. 157 -161
Abstract
The incidence of cholestatic jaundice in newborn babies is 1/2500 live births. Biliary atresia is
the most frequent single cause of neonatal cholestasis, its frequency is 1/10.000 live births. The
prognosis is strictly related to early surgical treatment since 80% of infants treated before 6 weeks
of age are jaundice-free at age 3 years. Over 50% of children with biliary atresia are referred
too late, after 6 weeks of age. Late onset haemorragic disease of the newborn may cause severe
bleeding in about 4/100.000 live births. The bleeding is often intracranial and may be associated
with permanent brain damage.
All forms of cholestatic jaundice should be treated with parenteral vitamin K and should be carefully
investigated to exclude biliary atresia.
Parole chiave
Suggerite dall'AI
Classificazione MeSH
Bibliografia
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3. Mieli-Vergani G, Howard ER, Portman B, Mowat AP: Late referral for biliary atresia. Missed opportunities for effective surgery. Lancet i, 412-3, 1989.
4. Maggiore G, Bernard O, Ryely CA, Hadchouel M, Lemonnier A, Alagille D: Normal g-glutamyl-transpeptidase activity identifies groups of infants with idiopathic cholestasis with poor prognosis. J Pediatr 111, 251-3, 1987.
5. Alagille D: Cholestasis in the first three months of life. Sem Liver Dis 6, 471-85, 1979.
6. Bernard O: Diagnostic des cholestases du nouveau-né. Progrés en Hépatogastroenterologie. Paris: Doin Editeurs, 1996, 281-8.
7. Bernard O: Plaidoyer pour le diagnostic précoce de l’atresie des voies biliaires. Douze erreurs à ne pas commettre. Arch Pédiatr 2, 937-9, 1995.