La curva che non sale: indizi clinici di una doppia verità

The paper reports the case of a 12-year-old girl presenting with severe stature growth deceleration and delayed puberty, alongside mild dysmorphic features noted since preschool age. Diagnostic workup revealed a dual clinical entity: Turner syndrome with hypergonadotropic hypogonadism (45,X0 karyotype) and the incidental finding of a left retroperitoneal mass. Biopsy and subsequent laparoscopic excision confirmed a favourable-prognosis ganglioneuroblastoma, requiring no chemotherapy. Following oncological clearance, growth hormone therapy and estrogenic induction of puberty were successfully initiated and led to optimal linear growth and pubertal progression. This case underscores the value of longitudinal auxological monitoring and the critical role of a coordinated multidisciplinary approach (paediatrician, geneticist, endocrinologist and oncologist) in managing complex paediatric conditions.