Immunosuppressive Agents

Arterite di Takayasu in paziente con febbre persistente sine focus

Demontis C, Stagi C.

2026/1 — pag. 56-56 — DOI

A 10-year-old boy was hospitalized for fever of unknown origin (FUO) and elevated inflammatory markers. After ruling out oncological causes, a total-body MRI revealed ‘cuff-like’ inflammation of the aorta that led to a diagnosis of Takayasu arteri...

Glomerulonefriti acute: tre facce della stessa medaglia

Iacono A, Cunsolo M, Spallino E, Di Natale K, Cusumano R, Corrado C, Pavone G, D’Alessandro MM, Corsello G.

2025/3 — pag. 159-164 — DOI

The phenotypic variability of a single pathology complicates the diagnostic and therapeutic approaches, particularly for its more complex and less common forms. The paper describes three clinical cases of post-infectious glomerulonephritis, all prese...

Leishmania e linfoistiocitosi emofagocitica (HLH)

Bratta A, Arcuri L, Micalizzi C

2025/2 — pag. 51-52 — DOI

Haemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening hyperinflammatory syndrome. The paper reports the case of a 5-month-old infant hospitalised with persistent fever, splenomegaly and significant inflammatory activation. After an ini...

Prima l'epatite autoimmune e poi la MICI... dopo tanto tempo

Izzo BP, Mainetti M, Aprile MR, Foschi F, Buzzi A, Marchetti F

2024/26 — pag. 4-5 — DOI

The authors describe the case of a girl with IBD that manifested 10 years after the diagnosis of seronegative hepatitis. ...

Vasculiti facili e difficili: cosa deve sapere e saper fare un pediatra

De Nardi L, Petrone MI, Benvenuto S, Natoli V, Abu-Rumeileh S, Castaldo B, De Benedetti F.

2023/5 — pag. 286-298 — DOI

Vasculitis is defined by a state of inflammation of the blood vessel walls. It can result in formation of either aneurysms or stenosis with ischemia and necrosis. The heterogeneity of clinical presentation depends on the type and size of the vessels ...

Malattia di Behçet: una sfida per il pediatra

Levantino L, Pastore S, Corona F, Lepore L, Tommasini L.

2022/5 — pag. 289-297 — DOI

Behçet’s disease (BD) is a rare chronic inflammatory condition associated with variable-vessel vasculitis, systemic involvement and relapsing course. It is characterized by a wide clinical heterogeneity, presenting with mucocutaneous, ocular, articul...

La granulomatosi eosinofilica con poliangioite: dalla pelle al cuore

M. Pavan, A. Agrusti, A. Trombetta, S. Pastore, A. Tommasini, V. Moressa, F. Marchetti, A. Taddio, A. Ventura

2020/9 — pag. 569-574 — DOI

Background - Eosinophilic granulomatosis with polyangiitis, formerly known as Churg-Strauss syndrome, is an extremely rare systemic vasculitis in the paediatric population. The hallmarks of eosinophilic granulomatosis with polyangiitis are a long his...

Febbre di origine sconosciuta (FUO): approccio diagnostico attraverso un caso clinico

D. Ursi, S. Puzone, C. Strisciuglio

2020/8 — pag. 519-525 — DOI

The paper reports the case of a 12-year-old female affected by ulcerative colitis and treated with double immunosuppressant therapy (methotrexate and infliximab). The patient presented with 7 day-lasting fever associated with pharyngotonsillar hypera...

Sembrava una Kawasaki, era una panarterite nodosa

J. Trombatore, R. Gallizzi

2020/3 — pag. 58-58

Infiammazione cronica e arterite di Takayasu

M. Cernich, L. Baggio, M. Guarnieri

2020/1 — pag. 23-23

LA COMPLESSITÀ DEL LUPUS ERITEMATOSO SISTEMICO

A. Taddio

2019/10 — pag. 627

Sindrome TINU: dall’occhio al rene andata e ritorno

L. Cortellazzo Wiel, G. Gortani, S. Pastore, S. Pensiero, M. Pennesi, A. Filpo, E. Valletta, A. Ventura

2019/2 — pag. 103-107

TINU stands for TubuloInterstitial Nephritis and Uveitis syndrome. The effective incidence of the disease is unknown, but it probably still remains largely underestimated. This can be explained by the frequent existence of a time-gap between the oc...

Epatite autoimmune e anemia aplastica

M. Pavan

2018/2

Una morfea pansclerotica: nulla è servito

S. Della Paolera, S. Pastore, M. Minute, M. Rabusin, L. Lepore, A. Ventura

2017/8 — pag. 531-532

The paper presents the case of a 12-year-old boy affected by circumscribed morphea that started with multiple skin lesions on both feet and hands. Despite different therapeutic approaches the disease evolved to an extremely disabling form of panscler...

Una morfea pansclerotica: nulla è servito

S. Della Paolera, S. Pastore, M. Minute, M. Rabusin, L. Lepore, A. Ventura

2017/8

The paper presents the case of a 12-year-old boy affected by circumscribed morphea that started with multiple skin lesions on both feet and hands. Despite different therapeutic approaches the disease evolved to an extremely disabling form of panscler...

Il trattamento della sindrome nefrosica cortico-sensibile

V. Murgia, F. Pugliese, F. Emma, G. Montini, M. Pennesi

2016/5 — pag. 297-302

Nephrotic cortico-sensitive syndrome is a chronic disease difficult to manage. Indeed, it presents a relapse risk in about 90% of cases and it may develop steroid dependence/ frequent relapse in about 50% of children. The nephrologist and the paedi...

Cosa deve sapere il pediatra della linfoistiocitosi emofagocitica attraverso i casi degli specializzandi

S. Lega, F. Dell’Acqua, M. Minute, F. Vendemini, C. Cattelani

2015/7 — pag. 431-441

Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening syndrome caused by severe hypercytokinemia due to a highly stimulated but ineffective immune response. HLH is not a disease by its own but is rather a common final consequen...

Alloimmunizzazione post-trasfusionale: terapia immunosoppressiva con rituximab e steroidi in una bambina affetta da drepanocitosi

E. Brivio, A. Cattoni, M. Pasetti

2014/9

Non cammina bene, ha “tremori” e gli occhi sembra che danzino...

M. Grassi, F. De Leonardis, P. Muggeo, M. Sesta, G. Paradies, N. Santoro

2014/7 — pag. 445-450

The paper reports the case of a 15-month-old girl who presented with abnormalities of gait, myoclonus and opsoclonus. Paediatric opsoclonus-myoclonus syndrome is associated in more than 50% to a neuroblastoma, generally with favorable prognosis. St...

Aplasie midollari acquisite in età pediatrica: raccomandazioni diagnostico-terapeutiche

Gruppo di Lavoro “Insufficienze Midollari” dell’AIEOP

2014/6 — pag. 383-389

Acquired Aplastic Anaemia (AA) is a rare heterogeneous disease characterized by pancytopoenia and hypoplastic bone marrow. The incidence is 2-3 millions per year (all age groups) in Europe, but is higher in East Asia. The pathogenesis of AA is comp...

Miocardite: la grande simulatrice

E. Benelli, M. Starc, E. Berton, M. Anzini, A. Benettoni, A. Ventura, G. Sinagra

2013/7 — pag. 429-434

Myocarditis is a rare, but life threatening disease in childhood. It is most often due to common viral infections; less commonly, it may result from bacterial infections, immune mediated diseases or chemotherapy. Myocarditis may present with unspec...

Una mancata cataratta

D. Ferrara, A. Macaluso

2013/2 — pag. 123-124

The case of a six-year-old child with idiopathic uveitis that initially was difficult to diagnose is described. Once the correct diagnosis was made, the little patient was adequately treated with immunosuppressants, which determined the clinical ...

Una mancata cataratta

D. Ferrara, A. Macaluso

2013/2

The case of a six-year-old child with idiopathic uveitis that initially was difficult to diagnose is described. Once the correct diagnosis was made, the little patient was adequately treated with immunosuppressants, which determined the clinical reso...

Malattia reumatologica, terapia immunosoppressiva e vaccinazione: rischi ed efficacia

2012/10 — pag. 662-663

Le vasculiti “maggiori” in età pediatrica

M. Pavan, F. Marchetti, L. Lepore

2011/4 — pag. 223-228

The most common vasculitides in children are Schönlein-Henoch purpura and Kawasaki disease, both of which are usually easy to diagnose and treat and have a good prognosis. Nevertheless, the typical adult vasculitides, such as Takayasu arteritis, We...

L’epatopatia della malattia celiaca: uno spettrodi lesioni con una comune patogenesi?

S. Caprai, G. Maggiore

2010/6 — pag. 383-386

A wide spectrum of liver injuries in children and adults may be related to celiac disease (CD) and in particular: 1) a mild parenchymal damage characterized by absence of clinical sign or symptom of a chronic liver disease and by non-specific histo...

I farmaci delle malattie infiammatorie croniche: dall’empirismo alla medicina molecolare

Giulia Gortani, Erica Valencic, Alberto Tommasini, Loredana Lepore

2007/6 — pag. 381-385

Chronic inflammatory diseases still represent a very dramatic problem in pediatric age. Therapeutic strategies are improving very quickly, but a complete control of disease progression is still a challenge. In a series of articles we try to address a...

Le priorità associate all’uso dei farmaci “off-label”

F. Marchetti, J. Bua, S. Demarini, et al.

2005/8 — pag. 527-531

Two thirds of the drugs prescribed for children are off-label. However, off-label is not synonymous with incorrect, since it often represents the most rational, evidence-based therapy. Existing data on the use of off-label in children are based on ...

Tremore e corea da alte dosi di cotrimossazolo in una bambina con infezione polmonare da Pneumocystis carinii

2004/11 — pag. 725-725

The Authors describe a case of a child with interstitial lung disease caused by Pneumocystis carinii pneumonia who developed tremors and choreic movements after treatment with high doses of trimethoprim-sulfamethoxazole. The patient developed immu...

L’uveite nell’artrite idiopatica giovanile

ME. Zannin, et al.

2004/6 — pag. 383-388

Uveitis is a frequent complication of rheumatic diseases, and represents one of the main causes of visual loss in the pediatric age. In 80% of the cases anterior uveitis is associated with juvenile idiopathic arthritis (JIA) and is chronic and asym...

Tacrolimus unguento

M. Lazzerini, F. Marchetti, G. Longo

2004/2 — pag. 102-107

The safety and efficacy of tacrolimus - a macrolide with immunosuppressive properties - were proven in atopic dermatitis in several trials versus placebo and in two trials versus topical steroids. The drug, as a 0.03% ointment, has been now approve...

Il trapianto di intestino è di destra o di sinistra?

S. Amarri

2002/8 — pag. 509-512

Intestinal transplantation (IT) is an alternative to lifelong total parenteral nutrition (TPN) for cases of severe intestinal insufficiency with the following characteristics: venous access impossible, TPN-dependent liver disease, recurrent sepsis,...

FEGATO: AUTOIMMUNITÅ, TRAPIANTO, INFEZIONEEpatite autoimmune: cinquant’anni e non li dimostra!

G. Maggiore, M. Sciveres

2002/5 — pag. 291-310

Autoimmune hepatitis (AIH) is an uncommon disease occurring mainly in women and characterised by the morphological changes of interface hepatitis on liver biopsy, hypergammaglobulinemia, elevated serum aminotransferases, and circulating autoantibod...

Benedetta e Marco: una Malattia Infiammatoria Cronica Intestinale da subito.

C. Trevisio, S. Martelossi, G. Palla, A. Ventura

2002/1

La azatioprina nel trattamento della Malattia Infiammatoria Cronica Intestinale in pediatria

S. Minisini, S. Facchini, S. Martellossi, A. Ventura

2001/8

Epatiti autoimmuni attorno all’anno 2000

I. Giuseppin, S. Martelossi, L. Lepore, G. Torre, I. Bruno,A. Ventura

2001/8 — pag. 499-508

Diagnosis of autoimmune hepatitis (AH) is based on: exclusion of viral genetic or tossic etiology, presence of non-organ-specific antibodies (SMA, ANA or LKM1); increased G immunoglobulin, typical histological features; response to immunosuppressiv...

L’azatioprina nel trattamento della malattia infiammatoria cronica intestinale in Pediatria

S. Minisini, S. Facchini, S. Martelossi, A. Ventura

2001/8 — pag. 545-548

28 children with IBD (mean age 14.7) received azathioprine (AZA) in addition to corticosteroids. Out of them, 17 are still receiving AZA, 11 had to discontinue the treatment because of adverse effects or other reasons. With reference to the Crohn...

Quando l’epatite e l’anemia si alternano

C. Benucci, C. Trapani, F. Mannelli, I. Sforzi, M. Resti

2001/4 — pag. 255-256

Un nuovo farmaco nella cura dell'artrite reumatoide: la leflunomide

G. Bartolozzi

1999/6

Un nuovo farmaco nella cura dell'artrite reumatoide: la leflunomide

G. Bartolozzi

1999/5

Costi e salute: fumare (= morire) per risparmiare?Fibrosi cistica: tre notizieObesità ed ereditarietàUn farmaco contro l’influenzaFalsa prevenzioneIodio e mortalità infantileTonsillite streptococcicaPredizione dell’allergia a inalantiClub del CrohnUn immuno-soppressore topico nella cura della dermatite atopicaSupplementi di calcio alla madre durante l’allattamento?

1997/8 — pag. 485-486