Aggiornamento monografico
Lectina legante il mannosio e suscettibilità alle infezioni
MANNOSE-BINDING LECTIN AND SUSCEPTIBILITY TO INFECTIONS
FABIO CARDINALE1, ANNA CALÒ1, RAFFAELLA CAVALLONE1, ELIO COSTANTINO2, MARIA S. LOFFREDO1, GAIA IACOVIELLO1, LUCIO ARMENIO1
1Clinica Pediatrica III, Sezione di Immunoallergologia e Broncopneumologia Pediatrica, Dipartimento di Biomedicina dell’Età Evolutiva, Università di Bari;
2Divisione di Pneumologia, AO Policlinico di Bari
Marzo 2002 - pagg. 155 -160
Abstract
Mannose-binding lectin (MBL) is an acute phase protein, belonging to the collectins family,
involved in host innate immunity. It binds to surface mannose-rich glycoproteins of several microorganisms,
inducing phagocytosis by opsonic and complement activating properties. Both
heterozygous and homozygous carriers of MBL-gene variant alleles seem more susceptible to
some infections. However, low serum MBL levels are not likely the only cause of clinical illness.
More probably an overt clinical pathology occurrs when an MBL-deficient status associates
with some other immune defect or disease. Recent studies have shown an association between
MBL-gene variant alleles and meningococcal-disease susceptibility. In addition, a low-producing
MBL gene phenotype seems to be associated with a poor prognosis in cystic fibrosis.
Some evidence also exists about a role of MBL in some autoimmune diseases.
Parole chiave
Suggerite dall'AI
Classificazione MeSH
Bibliografia
1. Medzhitov R, Janeway C jr. Innate immunity.
N Engl J Med 2000;343:338-44.
2. Travis S, Singh PH, Welsh MJ. Antimicrobial peptides and proteins in the innate defense of the airway surface. Curr Opin Immunol 2001;13:89-95.
3. Ottinger CA, Johnson SC, Ewart KW, et al. Enhancement of anti-Aeromonas salmonicida activity in Atlantic salmon (salmo salar) macrophage by a mannose-binding lectin. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1999;123:53-9.
4. Turner MW. Mannose-binding lectin: the pluripotent molecole of the innate immune system. Immunol Today 1996;17:532-9.
5. Babovic-Vuksanovic D, Snow K, Ten RM. Mannose-binding lectin (MBL) deficiency. Variant alleles in a Midwestern population of the United States. Ann Allergy Asthma Immunol 1999;82:134-41.
6. Thiel S, Bjerke BT, Poulsen LK, et al. Ontogeny of human mannan-binding protein, a lectin of the innate immune system. Pediatr Allergy Immunol 1995;6:20-3.
7. Matsushita M, Fujita T. Activation of the classical complement pathway by mannosebinding protein in association with a novel C1s-like serine protease. J Exp Med 1992; 176:1497-502.
8. Thiel S, Vorup-Jensen T, Stover CM, et al. A second serine protease associated with mannan- binding lectin that activates complement. Nature 1997;386:506-10.
9. Gadjeva M, Thiel S, Jensenius JC. The mannan- binding-lectin pathway of the innate immune response. Curr Opin Immunol 2001; 13:74-8
10. Taylor ME, Brickell PM, Craig RK, Summerfield JA. Structure and evolutionary origin of the gene encoding a human serum mannose- binding protein. Biochem J 1989;262:763- 71.
11. Garred P, Madsen HO, Svejgaard A. Genetics of human-binding protein. In: Ezekowitz RAB, Sastry K, Reid KBM (eds). Collectins and innate immunity. RG Landes. Austin, TX, 1996:139-64.
12. Lipscombe RJ, Sumiya M, Hill AV, et al. High frequencies in African and non-African populations of independent mutations in the mannose-binding protein gene. Hum Mol Genet 1992;1:709-15.
13. Mead R, Jack D, Pembrey M, et al. Mannose- binding lectin alleles in a prospectively recruited UK population. Lancet 1997;349: 1669-70.
14. Lipscombe RJ, Sumiya M, Summerfield JA, Turner MW. Distinct physico-chemical characteristics of human binding protein (MBP) expressed by individuals of different phenotype. Immunology 1995;85:660-7.
15. Madsen HO, Garred P, Kurtzhals JA, et al. A new frequent allele is the missing link in the structural polymorphism of the human mannan- binding protein. Immunogenetics 1994; 40:37-44.
16. Neth O, Jack DL, Dodds AW, et al. Mannose- binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immunity 2000;68:688-93.
17. Kase T, Suzuki Y, Kaway T, et al. Human mannan-binding lectin inhibits the infection of influenza A virus without complement. Immunology 1999;97:385-92.
18. Saifuddin M, Hart ML, Gewurz H, et al. Interaction of mannose-binding lectin with primary isolates of human immunodeficiency virus type 1. J Gen Virol 2000;81:949-55.
19. Swanson AF, Ezekowitz RA, Lee A, et al. Human mannose-binding protein inhibits infection of HeLA cells by Chlamydia trachomatis. Infect Immunity 1998;66:1607-12.
20. Green PJ, Feizi T, Stoll MS, et al. Recognition of the major cell surface glycoconjugates of Leishmania parasites by the human serum mannan-binding protein. Mol Biochem Parasitol 1994;66:319-28.
21. Turner MW, Super M, Singh S, et al. Molecular basis of a common opsonic defect. Clin Exp Allergy 1991;21(suppl.1):182-8.
22. Soothill JF, Harvey BAM. Defective opsonization: a common immunity deficiency. Arch Dis Child 1976;51:91-9.
23. Super M, Thiel S, Lu J, et al. Association of low levels of mannan-binding protein with a common defect of opsonisation. Lancet 1989; 2:1236-9.
24. Sumiya M, Super M, Tabona P, et al. Molecular basis of opsonic defect in immunodeficient children. Lancet 1991;337:1569-70.
25. Miller ME, Seals J, Kaye R, Levinsky LC. A familial, plasma associated defect of phagocytosis: a new cause of recurrent bacterial infections. Lancet 1968;2:60-3.
26. Candy DCA, Larcher VF, Tripp JH, et al. Yeast opsonisation in children with chronic diarrhoeal states. Arch Dis Child 1980;55:189- 93.
27. Richardson VF, Larcher VF, Price JF. A common congenital immunodeficiency predisposing to infection and atopy in infancy. Arch Dis Child 1983;58:799-802.
28. Summerfield JA, Sumiya M, Levin M, Turner MW. Association of mutations in mannose binding protein gene with childhood infections in consecutive hospital series. Br Med J 1997;314:1229-32.
29. Koch A, Melbye M, Soensen P, et al. Acute respiratory tract infections and mannosebinding lectin insufficiency during early childhood. JAMA 2001;285:1316-21.
30. Garred P, Madsen HO, Hofmann B, Svejgaard A. Increased frequency of homozygosy of abnormal mannan-binding protein alleles in patients with suspected immunodeficiency. Lancet 1995;346:941-3.
31. Ten RM, Carmona EM, Babovic-Vuksanovic D, Katzmann JA. Mannose-binding lectin deficiency associated with neutrophil chemotactic unresponsiveness to C5a. J Allergy Clin Immunol 1999;104:419-24.
32. Summerfield JA, Ryder S, Sumyia M, et al. Mannose binding protein gene mutations associated with unusual and severe infections in adults. Lancet 1995;345:886-9.
33. Aittoniemi J, Baer M, Soppi E, Vesikari T, Miettinen A. Mannan binding lectin deficiency and concomitant immunodefects. Arch Dis Child 1998;78:245-8.
34. Hibberd ML, Sumiya M, Summerfield JA, Booy R, Levin M and the Meningococcal Research Group. Association of variants of the gene for mannose-binding lectin with susceptibility to meningococcal disease. Lancet 1999; 353:1049-53.
35. Bax WA, Cluysenaer OJJ, Bartelink AKM, et al. Association of familial deficiency of mannose- binding lectin and meningococcal disease. Lancet 1999;354:1094-5.
36. Garred P, Pressler T, Masdsen HO, et al. Association of mannose-binding lectin gene with severity of lung disease and survival in cystic fibrosis. J Clin Invest 1999;104:431-7.
37. Gabolde M, Guilloud-Bataille M, Feingold J, Besmond C. Association of variant alleles of mannose binding lectin with severity of pulmonary disease in cystic fibrosis: cohort study. Br Med J 1999;319:1166-7.
38. Gabolde M, Hubert D, Guilloud-Bataille M, et al. The mannose binding lectin gene influences the severity of chronic liver disease in cystic fibrosis. J Med Genet 2001;38:310-1. 39.) Neth O, Hann I, Turner MW, Klein NJ. Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective study. Lancet 2001;358:614-8.
40. Peterslund NA, Koch C, Jensenius J, Thiel S. Association between deficiency of mannosebinding lectin and severe infections after chemotherapy. Lancet 2001;358:637-8.
41. Garred P, Madsen HO, Halberg P, et al. Mannose-binding lectin polymorphism and susceptibility to infection in systemic lupus erythematosus. Arthritis Rheum 1999;42: 2145-52.
42. Kilpatrick DC, Bevan BH, Liston WA. Association between mannan binding protein deficiency and recurrent miscarriage. Hum Reprod 1995;10:2501-5.
43. Malhotra R, Willis AC, Lopez Bernal A, et al. Mannan-binding protein levels in amniotic fluid during gestation and its interaction with collectin receptor from amnion cells. Immunology 1994;82:439-44.
44. Garred P, Madsen HO, Balslev U, et al. Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose- binding lectin. Lancet 1997;349:236-40.
45. Graudal NA, Madsen HO, Tarp U, et al. The association of variant mannose-binding lectin genotypes with radiographic outcome in rheumatoid arthritis. Arthritis Rheum 2000; 43:515-21.
46. Wang ZY, Morinobu A, Kanagawa S, Kumagai S. Polymorphisms of the mannose binding lectin gene in patients with Sjögren’s syndrome. Ann Rheum Dis 2001;60:483-6.
47. Yong M, Uemura K, Oka S, et al. Antitumor activity of mannan-binding protein in vivo as revealed by a virus expression system: mannan-binding protein dependent cell-mediated cytotoxicity. Proc Natl Acad Sci USA 1999;96:371-5.
48. Garred P, Harboe M, Ottinger T, et al. Dual role of human mannan-binding protein in infections: another case of eterosis? Eur J Immunogen 1994;21:125-31.
2. Travis S, Singh PH, Welsh MJ. Antimicrobial peptides and proteins in the innate defense of the airway surface. Curr Opin Immunol 2001;13:89-95.
3. Ottinger CA, Johnson SC, Ewart KW, et al. Enhancement of anti-Aeromonas salmonicida activity in Atlantic salmon (salmo salar) macrophage by a mannose-binding lectin. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1999;123:53-9.
4. Turner MW. Mannose-binding lectin: the pluripotent molecole of the innate immune system. Immunol Today 1996;17:532-9.
5. Babovic-Vuksanovic D, Snow K, Ten RM. Mannose-binding lectin (MBL) deficiency. Variant alleles in a Midwestern population of the United States. Ann Allergy Asthma Immunol 1999;82:134-41.
6. Thiel S, Bjerke BT, Poulsen LK, et al. Ontogeny of human mannan-binding protein, a lectin of the innate immune system. Pediatr Allergy Immunol 1995;6:20-3.
7. Matsushita M, Fujita T. Activation of the classical complement pathway by mannosebinding protein in association with a novel C1s-like serine protease. J Exp Med 1992; 176:1497-502.
8. Thiel S, Vorup-Jensen T, Stover CM, et al. A second serine protease associated with mannan- binding lectin that activates complement. Nature 1997;386:506-10.
9. Gadjeva M, Thiel S, Jensenius JC. The mannan- binding-lectin pathway of the innate immune response. Curr Opin Immunol 2001; 13:74-8
10. Taylor ME, Brickell PM, Craig RK, Summerfield JA. Structure and evolutionary origin of the gene encoding a human serum mannose- binding protein. Biochem J 1989;262:763- 71.
11. Garred P, Madsen HO, Svejgaard A. Genetics of human-binding protein. In: Ezekowitz RAB, Sastry K, Reid KBM (eds). Collectins and innate immunity. RG Landes. Austin, TX, 1996:139-64.
12. Lipscombe RJ, Sumiya M, Hill AV, et al. High frequencies in African and non-African populations of independent mutations in the mannose-binding protein gene. Hum Mol Genet 1992;1:709-15.
13. Mead R, Jack D, Pembrey M, et al. Mannose- binding lectin alleles in a prospectively recruited UK population. Lancet 1997;349: 1669-70.
14. Lipscombe RJ, Sumiya M, Summerfield JA, Turner MW. Distinct physico-chemical characteristics of human binding protein (MBP) expressed by individuals of different phenotype. Immunology 1995;85:660-7.
15. Madsen HO, Garred P, Kurtzhals JA, et al. A new frequent allele is the missing link in the structural polymorphism of the human mannan- binding protein. Immunogenetics 1994; 40:37-44.
16. Neth O, Jack DL, Dodds AW, et al. Mannose- binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immunity 2000;68:688-93.
17. Kase T, Suzuki Y, Kaway T, et al. Human mannan-binding lectin inhibits the infection of influenza A virus without complement. Immunology 1999;97:385-92.
18. Saifuddin M, Hart ML, Gewurz H, et al. Interaction of mannose-binding lectin with primary isolates of human immunodeficiency virus type 1. J Gen Virol 2000;81:949-55.
19. Swanson AF, Ezekowitz RA, Lee A, et al. Human mannose-binding protein inhibits infection of HeLA cells by Chlamydia trachomatis. Infect Immunity 1998;66:1607-12.
20. Green PJ, Feizi T, Stoll MS, et al. Recognition of the major cell surface glycoconjugates of Leishmania parasites by the human serum mannan-binding protein. Mol Biochem Parasitol 1994;66:319-28.
21. Turner MW, Super M, Singh S, et al. Molecular basis of a common opsonic defect. Clin Exp Allergy 1991;21(suppl.1):182-8.
22. Soothill JF, Harvey BAM. Defective opsonization: a common immunity deficiency. Arch Dis Child 1976;51:91-9.
23. Super M, Thiel S, Lu J, et al. Association of low levels of mannan-binding protein with a common defect of opsonisation. Lancet 1989; 2:1236-9.
24. Sumiya M, Super M, Tabona P, et al. Molecular basis of opsonic defect in immunodeficient children. Lancet 1991;337:1569-70.
25. Miller ME, Seals J, Kaye R, Levinsky LC. A familial, plasma associated defect of phagocytosis: a new cause of recurrent bacterial infections. Lancet 1968;2:60-3.
26. Candy DCA, Larcher VF, Tripp JH, et al. Yeast opsonisation in children with chronic diarrhoeal states. Arch Dis Child 1980;55:189- 93.
27. Richardson VF, Larcher VF, Price JF. A common congenital immunodeficiency predisposing to infection and atopy in infancy. Arch Dis Child 1983;58:799-802.
28. Summerfield JA, Sumiya M, Levin M, Turner MW. Association of mutations in mannose binding protein gene with childhood infections in consecutive hospital series. Br Med J 1997;314:1229-32.
29. Koch A, Melbye M, Soensen P, et al. Acute respiratory tract infections and mannosebinding lectin insufficiency during early childhood. JAMA 2001;285:1316-21.
30. Garred P, Madsen HO, Hofmann B, Svejgaard A. Increased frequency of homozygosy of abnormal mannan-binding protein alleles in patients with suspected immunodeficiency. Lancet 1995;346:941-3.
31. Ten RM, Carmona EM, Babovic-Vuksanovic D, Katzmann JA. Mannose-binding lectin deficiency associated with neutrophil chemotactic unresponsiveness to C5a. J Allergy Clin Immunol 1999;104:419-24.
32. Summerfield JA, Ryder S, Sumyia M, et al. Mannose binding protein gene mutations associated with unusual and severe infections in adults. Lancet 1995;345:886-9.
33. Aittoniemi J, Baer M, Soppi E, Vesikari T, Miettinen A. Mannan binding lectin deficiency and concomitant immunodefects. Arch Dis Child 1998;78:245-8.
34. Hibberd ML, Sumiya M, Summerfield JA, Booy R, Levin M and the Meningococcal Research Group. Association of variants of the gene for mannose-binding lectin with susceptibility to meningococcal disease. Lancet 1999; 353:1049-53.
35. Bax WA, Cluysenaer OJJ, Bartelink AKM, et al. Association of familial deficiency of mannose- binding lectin and meningococcal disease. Lancet 1999;354:1094-5.
36. Garred P, Pressler T, Masdsen HO, et al. Association of mannose-binding lectin gene with severity of lung disease and survival in cystic fibrosis. J Clin Invest 1999;104:431-7.
37. Gabolde M, Guilloud-Bataille M, Feingold J, Besmond C. Association of variant alleles of mannose binding lectin with severity of pulmonary disease in cystic fibrosis: cohort study. Br Med J 1999;319:1166-7.
38. Gabolde M, Hubert D, Guilloud-Bataille M, et al. The mannose binding lectin gene influences the severity of chronic liver disease in cystic fibrosis. J Med Genet 2001;38:310-1. 39.) Neth O, Hann I, Turner MW, Klein NJ. Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective study. Lancet 2001;358:614-8.
40. Peterslund NA, Koch C, Jensenius J, Thiel S. Association between deficiency of mannosebinding lectin and severe infections after chemotherapy. Lancet 2001;358:637-8.
41. Garred P, Madsen HO, Halberg P, et al. Mannose-binding lectin polymorphism and susceptibility to infection in systemic lupus erythematosus. Arthritis Rheum 1999;42: 2145-52.
42. Kilpatrick DC, Bevan BH, Liston WA. Association between mannan binding protein deficiency and recurrent miscarriage. Hum Reprod 1995;10:2501-5.
43. Malhotra R, Willis AC, Lopez Bernal A, et al. Mannan-binding protein levels in amniotic fluid during gestation and its interaction with collectin receptor from amnion cells. Immunology 1994;82:439-44.
44. Garred P, Madsen HO, Balslev U, et al. Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose- binding lectin. Lancet 1997;349:236-40.
45. Graudal NA, Madsen HO, Tarp U, et al. The association of variant mannose-binding lectin genotypes with radiographic outcome in rheumatoid arthritis. Arthritis Rheum 2000; 43:515-21.
46. Wang ZY, Morinobu A, Kanagawa S, Kumagai S. Polymorphisms of the mannose binding lectin gene in patients with Sjögren’s syndrome. Ann Rheum Dis 2001;60:483-6.
47. Yong M, Uemura K, Oka S, et al. Antitumor activity of mannan-binding protein in vivo as revealed by a virus expression system: mannan-binding protein dependent cell-mediated cytotoxicity. Proc Natl Acad Sci USA 1999;96:371-5.
48. Garred P, Harboe M, Ottinger T, et al. Dual role of human mannan-binding protein in infections: another case of eterosis? Eur J Immunogen 1994;21:125-31.