Problemi speciali
Utilitā diagnostica del dosaggio della calprotectina fecale in etā pediatrica
DIAGNOSTIC VALUE OF FAECAL CALPROTECTIN IN PAEDIATRIC AGE
Roberto Berni Canani, Maria Passaro, Cuono Puzone
Dipartimento di Pediatria e Laboratorio Europeo per lo Studio delle Malattie Indotte da Alimenti
Universitā degli Studi Federico II, Napoli
Aprile 2009 - pagg. 239 -242
Abstract
Determination of the faecal calprotectin (FC), a leucocyte-derived protein, is becoming a valuable tool in paediatric clinical practice for the diagnosis and monitoring of several diseases of the gastrointestinal tract. FC is a sensitive, but not specific, marker to easily detect inflammation throughout the whole gastrointestinal tract. It may help in identifying an organic disease characterized by mucosal inflammation and in the differential diagnosis of functional bowel disorders. FC is increasingly used to monitor the efficacy of treatments in inflammatory bowel diseases and to assess the severity of mucosal inflammation.
Parole chiave
Suggerite dall'AI
Classificazione MeSH
Bibliografia
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3. Robinson MJ, Tessier P, Poulsom R, Hogg N. The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells. J Biol Chem 2002;277:3658-65.
4. Loomans HJ, Hahn BL, Li QQ, Phadnis SH, Sohnle PG. Histidine-based zinc-binding sequences and the antimicrobial activity of calprotectin. J Infect Dis 1998;177:812-4.
5. Damms A, Bischoff SC. Validation and clinical significance of a new calprotectin rapid test for the diagnosis of gastrointestinal diseases. Int J Colorectal Dis 2008;23:985-92.
6. Berni Canani R, Rapacciuolo L, Romano MT, et al. Diagnostic value of faecal calprotectin in paediatric gastroenterology clinical practice. Dig Liver Dis 2004;36:467-70.
7. Berni Canani R, Romano MT, Terrin G, et al. Fecal calprotectin in a useful diagnostic tool in pediatric gastroenterology. Ital J Pediatr 2005;31:89-94.
8. Olafsdottir E, Aksnes L, Fluge G, et al. Faecal calprotectin levels in infants with infantile colic, healthy infants, children with inflammatory bowel disease, children with recurrent abdominal pain and healthy children. Acta Paediatr 2002;91:45-50.
9. Campeotto F, Butel MJ, Kalach N, et al. High faecal calprotectin concentration in newborn infants. Arch Dis Child Fetal Neonatal 2004;89:F353-5.
10. Bruzzese E, Raia V, Gaudiello G, et al. Intestinal inflammation is a frequent feature of cystic fibrosis and is reduced by probiotic administration. Aliment Pharmacol Ther 2004; 20:813-9.
11. Papp M, Norman GL, Altorjay I, Lakatos PL. Utility of serological markers in inflammatory bowel diseases: gadget or magic? World J Gastroenterol 2007;13:2028-36.
12. Berni Canani R, de Horatio LT, Terrin G, et al. Combined use of non invasive tests is useful in the initial diagnostic approach to a child with suspected inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2006;42:9-15.
13. Berni Canani R, Terrin G, Rapacciuolo L, et al. Faecal calprotectin as reliable non-invasive marker to assess the severity of mucosal inflammation in children with inflammatory bowel disease. Dig Liver Dis 2008;40:547-53.
2. Doussiere J, Bouzidi F, Vignais PV. The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils. Eur J Biochem 2002;269:3246-55.
3. Robinson MJ, Tessier P, Poulsom R, Hogg N. The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells. J Biol Chem 2002;277:3658-65.
4. Loomans HJ, Hahn BL, Li QQ, Phadnis SH, Sohnle PG. Histidine-based zinc-binding sequences and the antimicrobial activity of calprotectin. J Infect Dis 1998;177:812-4.
5. Damms A, Bischoff SC. Validation and clinical significance of a new calprotectin rapid test for the diagnosis of gastrointestinal diseases. Int J Colorectal Dis 2008;23:985-92.
6. Berni Canani R, Rapacciuolo L, Romano MT, et al. Diagnostic value of faecal calprotectin in paediatric gastroenterology clinical practice. Dig Liver Dis 2004;36:467-70.
7. Berni Canani R, Romano MT, Terrin G, et al. Fecal calprotectin in a useful diagnostic tool in pediatric gastroenterology. Ital J Pediatr 2005;31:89-94.
8. Olafsdottir E, Aksnes L, Fluge G, et al. Faecal calprotectin levels in infants with infantile colic, healthy infants, children with inflammatory bowel disease, children with recurrent abdominal pain and healthy children. Acta Paediatr 2002;91:45-50.
9. Campeotto F, Butel MJ, Kalach N, et al. High faecal calprotectin concentration in newborn infants. Arch Dis Child Fetal Neonatal 2004;89:F353-5.
10. Bruzzese E, Raia V, Gaudiello G, et al. Intestinal inflammation is a frequent feature of cystic fibrosis and is reduced by probiotic administration. Aliment Pharmacol Ther 2004; 20:813-9.
11. Papp M, Norman GL, Altorjay I, Lakatos PL. Utility of serological markers in inflammatory bowel diseases: gadget or magic? World J Gastroenterol 2007;13:2028-36.
12. Berni Canani R, de Horatio LT, Terrin G, et al. Combined use of non invasive tests is useful in the initial diagnostic approach to a child with suspected inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2006;42:9-15.
13. Berni Canani R, Terrin G, Rapacciuolo L, et al. Faecal calprotectin as reliable non-invasive marker to assess the severity of mucosal inflammation in children with inflammatory bowel disease. Dig Liver Dis 2008;40:547-53.
Corrispondenza: berni@unina.it