Percorsi clinici
Pubarca precoce, irsutismo, amenorrea e bassa statura: quale diagnosi?
Premature adrenarche, hirsutism and primary amenorrea: which diagnosis?
Andrea Zucchini, Federico Marchetti
UOC di Pediatria e Neonatologia, AUSL di Ravenna, Ospedale di Faenza
Gennaio 2013 - pagg. 35 -38
Abstract
Non-classical congenital adrenal hyperplasia (NCCAH) is an autosomal recessive disease
that appears during childhood with hyperandrogenic symptoms. The article reports a
case of NCCAH due to 21-hydroxylase deficiency in a 14-year-old girl with premature
adrenarche, hirsutism and primary amenorrea. Premature adrenarche is a benign diagnosis,
but can also result from severe pathology, which makes it necessary to find the cause
of premature exposition to androgens. In conjunction with history and clinical examination,
first line investigations should include determination of serum androgen concentrations,
along with bone age, proceeding to synacthen stimulation test (for 17OHP levels)
and adrenal ultrasound if indicated.
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Classificazione MeSH
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Corrispondenza: a.zucchini@ausl.ra.it