Articolo speciale
Post-genomica della crescita e della pubertà
Post-genomics growth and puberty
Luigi Greco, Donatella Cielo
Dipartimento di Scienze Mediche Transazionali, Università Federico II, Napoli
Gennaio 2017 - pagg. 31 -37
Abstract
In the last 50 years the surveillance of children’s growth was based upon the adoption
of the graphs of percentiles of normal growth: there was no chance to explore the pattern
of growth of the individual child, more than declaring his normality/abnormality.
Recently, the cluster of gene expression related to three phases of growth (infancy,
adolescence and adulthood) has been identified. It may now be possible to monitor
the growth of the individual child through the next generation analysis of the profile of
gene expression of the single child. This information will offer a precise insight of the
metabolic processes that regulate the expression of specific cluster of gene. The direction
will be from linear or tridimensional measurements to a multidimensional estimation
of the growth “regulome”.
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Corrispondenza: dona_cielo@yahoo.it