L'esperienza che insegna
Emorragia e trombosi, le due facce del lupus eritematoso sistemico
Bleeding and thrombosis in systemic lupus erythematosus: two sides of the same coin
Mariangela Stinco1, Teresa Giani2, Ilaria Maccora1, Gabriele Simonini2, Rolando Cimaz2
1Universitŕ di Firenze
2SODc di Reumatologia, Ospedale Pediatrico “Meyer”, Firenze
Dicembre 2019 - pagg. 628 -630
Abstract
Systemic lupus erythematosus (SLE) is an inflammatory disease with autoimmune pathogenesis and chronic-relapsing course characterised by a wide and heterogeneous spectrum of manifestations and sometimes opposed coexisting clinical features. The paper reports the case of a young girl with immune thrombocytopenic purpura and antiphospholipid antibody syndrome and describes the complexity of therapeutic management linked to the risk of bleeding and thrombosis.
Parole chiave
Suggerite dall'AI
Classificazione MeSH
Contenuto riservato
Per leggere l'articolo completo è necessario effettuare il login.
Non sei ancora registrato? Registrati
Bibliografia
1. Petri M, Orbai A-M, Alarcón GS, et al. Derivation
and validation of the Systemic Lupus
International Collaborating Clinics classification
criteria for systemic lupus erythematosus.
Arthritis Rheum 2012;64(8):2677-86.
2. Inęs L, Silva C, Galindo M, et al; Rheumatic
Diseases Registry of the Portuguese Society
of Rheumatology; Registry of Systemic
Lupus Erythematosus Patients of the Spanish
Society of Rheumatology. Classification of
systemic lupus erythematosus: Systemic Lupus
International Collaborating Clinics versus
American College of Rheumatology Criteria.
A comparative study of 2,055 patients
from a real-life, international systemic lupus
erythematosus cohort. Arthritis Care Res
(Hoboken) 2015;67(8):1180-5.
3. Hartman EAR, van Royen-Kerkhof A, Jacobs
JWG, Welsing PMJ, Fritsch-Stork RDE.
Performance of the 2012 Systemic Lupus International
Collaborating Clinics classification
criteria versus the 1997 American College
of Rheumatology classification criteria in
adult and juvenile systemic lupus erythematosus.
A systematic review and meta-analysis.
Autoimmun Rev 2018;17(3):316-22.
4. Brandt JT, Triplett DA, Alving B, Scharrer
I. Criteria for the diagnosis of lupus anticoagulants:
an update. On behalf of the Subcommittee
on Lupus Anticoagulant/Antiphospholipid
Antibody of the Scientific and Standardisation
Committee of the ISTH. Thromb Haemost
1995;74(4):1185-90.
5. Miyakis S, Lockshin MD, Atsumi T, et al.
International consensus statement on an update
of the classification criteria for definite
antiphospholipid syndrome (APS). J Thromb
Haemost 2006;4:295-306.
6. Chighizola CB, Ubiali T, Meroni PL. Treatment
of thrombotic antiphospholipid syndrome:
the rationale of current management - an
insight into future approaches. J Immunol
Res 2015;2015:951424.
7. Artim-Esen B, Diz-Küçükkaya R, İnanç M.
The significance and management of thrombocytopenia
in antiphospholipid syndrome.
Curr Rheumatol Rep 2015;17(3):14.
8. Meroni PL, Moia M, Derksen RH, et al.
Venous thromboembolism in the antiphospholipid
syndrome: management guidelines
for secondary prophylaxis. Lupus 2003;12(7):
504-7.
9. Wincup C, Ioannou Y. The differences
between childhood and adult onset antiphospholipid
syndrome. Front Pediatr 2018;6:
362.
10. Cohen H, Hunt BJ, Efthymiou M, et al.;
RAPS trial investigators. Rivaroxaban versus
warfarin to treat patients with thrombotic antiphospholipid
syndrome, with or without systemic
lupus erythematosus (RAPS): a randomised,
controlled, open-label, phase 2/3,
non-inferiority trial. Lancet Haematol 2016;3
(9):e426-36.
11. Pengo V, Denas G, Zoppellaro G, et al. Rivaroxaban
vs warfarin in high-risk patients
with antiphospholipid syndrome. Blood 2018;
132(13):1365-71.
12. Berman H, Rodríguez-Pintó I, Cervera R,
et al; Catastrophic Antiphospholipid Syndrome
(CAPS) Registry Project Group (European
Forum on Antiphospholipid Antibodies).
Rituximab use in the catastrophic antiphospholipid
syndrome: descriptive analysis
of the CAPS registry patients receiving rituximab.
Autoimmun Rev 2013;12(11):1085-
90.
Corrispondenza: m.stinco@gmail.com
