Linee guida
La diagnosi di celiachia attraverso casi clinici interattivi
The diagnosis of coeliac disease through interactive clinical cases
Martina D’Agostin1, Arianna Traunero1, Chiara Zanchi2, Matteo Bramuzzo2, Sara Lega2, Jernej Dolinšek3
1Scuola di Specializzazione in Pediatria, Università di Trieste
2SS di Gastroenterologia Pediatrica, IRCCS Materno-Infantile “Burlo Garofolo”, Trieste
3Gastroenterology Unit of Pediatrics Department, University Medical Centre, Maribor (Slovenia)
Gennaio 2022 - pagg. 29 -32 | DOI: 10.53126/MEB41029
Abstract
Coeliac disease is an immune-mediated systemic disease that affects 1% of the population and it is caused by the ingestion of gluten in genetically predisposed subjects. Clinical manifestations and intestinal damage completely resolve once gluten is excluded from the diet, therefore the precocity of diagnosis is of primary relevance. Although considerable progress has been made in recent years, the wide spectrum of clinical manifestations still causes diagnostic delay. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) has recently published an update of the guidelines providing tools to optimize diagnostic skills. This work aims to summarize the main topics of the new guidelines through illustrative clinical cases.
Riassunto
La celiachia è una malattia sistemica immuno-mediata che colpisce l'1% della popolazione ed è causata dall'ingestione di glutine in soggetti geneticamente predisposti. Le manifestazioni cliniche e il danno intestinale si risolvono completamente una volta escluso il glutine dalla dieta, pertanto la precocità della diagnosi è di primaria importanza. Sebbene negli ultimi anni siano stati compiuti notevoli progressi, l'ampio spettro di manifestazioni cliniche causa ancora ritardi diagnostici. La Società Europea di Gastroenterologia, Epatologia e Nutrizione Pediatrica (ESPGHAN) ha recentemente pubblicato un aggiornamento delle linee guida che forniscono strumenti per ottimizzare le capacità diagnostiche. Questo lavoro si propone di sintetizzare i temi principali delle nuove linee guida attraverso casi clinici illustrativi.
Parole chiave
anticorpi anti-endomisiali IgA
anticorpi IgA anti-endomisiali
anticorpi IgA anti-transglutaminasi
Approccio senza biopsia
Celiachia potenziale
Coeliac disease
IgA anti-endomysial antibodies
IgA anti-transglutaminase antibodies
malattia celiaca
No-biopsy approach
Potential coeliac disease
Potenziale malattia celiaca
Suggerite dall'AI
Classificazione MeSH
Contenuto riservato
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Bibliografia
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Corrispondenza: martina.dagostin@gmail.com