Vaccinare
Reazioni avverse lievi e gravi (rare) ai vaccini: una revisione
ADVERSE VACCINE REACTIONS
GIORGIO BARTOLOZZI
Dipartimento di Pediatria, Università di Firenze
Dicembre 1997 - pagg. 643 -647
Abstract
Adverse reactions to vaccine vary from trivial
to severe. Mild reactions include systemic
symptoms (fever after DTP vaccine or
rash after live measles vaccine) or local flogosis
after DTP. Sterile abscesses may occur
after immunization with a variety of killed
vaccines and may be caused by the
inadvertent subcutaneous administration of
a vaccine intended for intramuscolar use.
Rare, serious consequences of vaccine use
that result in severe sequelae or death can
also occur impredictably. Examples are paralytic
polio after live polio vaccine or hypersensitivity
reactions to vaccine components
such as bovine or suine collagen,
neomycine, mercury. Egg allergy does not
represent a contraindication to vaccines
containing egg proteins. Health professionals
should know the specific reactions that
may be associated with the administration
of the most commonly used vaccines.
Parole chiave
Classificazione MeSH
Bibliografia
1. Beeler J, Varricchio F, Wise R: Thrombocytopenia
after immunization with measles
vaccines: review of the Vaccine Adverse Events Reporting System (1990 to 1994). Pediatr
Infect Dis J 15, 88-90, 1996.
2. Centers for Disease Control and Prevention (CDC): Update: vaccine side effects, adverse reactions, contraindications and precautions. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 45, N° RR-12, 1996.
3. Drachtman RA, Murphy S, Ettinger LJ et al: Exacerbation of chronic idiopathic thrombocytopenic purpura following measlesmumps- rubella immunization. Arch Pediatr Adolesc Med 148, 326-7, 1994.
4. Gale JL,Thapa PB, Wassilak SGF et al: Risk of serious acute neurological illness after immunization with diphteria-tetanus-pertussis vaccine. JAMA 271, 37-41, 1994.
5. James JM, Burks AW, Roberson PK et al: Safe administration of the measles vaccine to children allergic to eggs. N Engl J Med 332, 1262-6, 1995.
6. Kelso JM, Jones RT, Yuninger JW et al: Anaphylaxis to measles, mumps and rubella vaccine mediated by IgE to gelatin. J Allergy Clin Immunol 91, 867-72, 1993.
7. Miller E, Goldacre M, Pugh S et al: Risk of aseptic meningitis after measles, mumps and rubella vaccine in UK children. Lancet 341, 979-95, 1993.
8. Nieminen U, Peltola H, Syrjala MT et al: Acute thrombocytopenic purpura following measles, mumps and rubella vaccination. A report on 23 patients. Acta Paediatr 82, 267- 70, 1993.
9. Rantala J, Cherry JD, Shields WD et al: Epidemiology of Guillain-Barré syndrome in children: relationship of oral polio vaccine administration to occorrence. J Pediatr 124, 220-3, 1994.
2. Centers for Disease Control and Prevention (CDC): Update: vaccine side effects, adverse reactions, contraindications and precautions. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 45, N° RR-12, 1996.
3. Drachtman RA, Murphy S, Ettinger LJ et al: Exacerbation of chronic idiopathic thrombocytopenic purpura following measlesmumps- rubella immunization. Arch Pediatr Adolesc Med 148, 326-7, 1994.
4. Gale JL,Thapa PB, Wassilak SGF et al: Risk of serious acute neurological illness after immunization with diphteria-tetanus-pertussis vaccine. JAMA 271, 37-41, 1994.
5. James JM, Burks AW, Roberson PK et al: Safe administration of the measles vaccine to children allergic to eggs. N Engl J Med 332, 1262-6, 1995.
6. Kelso JM, Jones RT, Yuninger JW et al: Anaphylaxis to measles, mumps and rubella vaccine mediated by IgE to gelatin. J Allergy Clin Immunol 91, 867-72, 1993.
7. Miller E, Goldacre M, Pugh S et al: Risk of aseptic meningitis after measles, mumps and rubella vaccine in UK children. Lancet 341, 979-95, 1993.
8. Nieminen U, Peltola H, Syrjala MT et al: Acute thrombocytopenic purpura following measles, mumps and rubella vaccination. A report on 23 patients. Acta Paediatr 82, 267- 70, 1993.
9. Rantala J, Cherry JD, Shields WD et al: Epidemiology of Guillain-Barré syndrome in children: relationship of oral polio vaccine administration to occorrence. J Pediatr 124, 220-3, 1994.