Articolo speciale
Allergia agli alimenti, reazioni crociate e biotecnologie agroalimentari
FOOD ALLERGY, CROSS-REACTIONS AND STORAGE TECHNIQUES
ROBERTO RONCHETTI, MARIA PIA VILLA
Clinica Pediatrica, Azienda Ospedaliera “S. Andrea”, II Facoltà di Medicina e Chirurgia, Università “La Sapienza”, Roma
Gennaio 2004 - pagg. 31 -37
Abstract
Food allergies can be divided into two groups, the first one comprising classic tropho-allergies,
which appear during the first year of life or early childhood, and are accompanied by
eczema, hives, enteropathy, shock; and the second one affecting older children and adults,
which is associated with cross-reactions between tropho-allergens and pneumo-allergens. The
latter can be attributed to a large extent to enzymes and proteins - which are not species-specific
and which are stimulated by accelerated ripening and storage techniques (chitinase,
“plant defence related proteins”) - that are responsible for latex allergy, oral-allergic, shock
and asthma syndromes, and intestinal troubles. These allergies are not species-specific because
the aforementioned enzymes and proteins are common to various plants.
Classificazione MeSH
Bibliografia
1. Schafer T, Bohler E, Ruhdorfer S, et al. Epidemiology
of food allergy/food intolerance in
adults: associations with other manifestations
of atopy. Allergy 2001;56:1172-9.
2. Niestijl-Jansen J, Kardinaal AFM, Huijbers G, et al. Prevalence of food allergy and intolerance in the adult Dutch population. J All Clin Immunol 1994;93:446-56.
3. Bindslev-Jensen C. ABC of allergies Food Allergy. BMJ 1998; 516: 1299-302. 3a. ” Position Paper” EAACI pubblicata in Allergy 2001;9:813-24.
4. Sampson A. Use of food-challenge tests in children. Lancet 2001;358:1832-3.
5. May C. Objective clinical and laboratory studies of immediate hypersensibility reaction to food in asthmatic children. J All Clin Immunol 1976;58:500-15.
6. Caffarelli C, Petroccione T. False-negative food challenges in children with suspected food allergy. Lancet 2001;1:358:1871-2.
7. Jones SM, Mangolfi CF, Cooke SK, et al. Immunologic cross reactivity among cereals grains and grasses in children with food hypersensitivity. J All Clin Immunol 1995;96:341-51.
8. Rodriguez J, Crespo JF, Lopez-Rubio A, et al. Clinical cross reactivity among foods of the Rosaceae family. J All Clin Immunol 2000; 106:183-9.
9. Hill DJ, Hosking CS, Heine RG. Clinical spectrum of food allergy in children in Australia and South-East Asia: identification and targets for treatment. Ann Med 1999;31:272- 81.
10. Ishida T, Murai K, Yasuda T, et al. Oral allergy syndrome in patients with Japanese cedar pollinosis. Nippon Jibiinkoka Gakkai Kaiko 2000 Mar;103(3):199-205.
11. Host A, Halken S. A prospective study of cow milk allergy in Danish infants during the first three years of life: clinical course in relation to clinical and immunological type of hypersensitivity reaction. Allergy 1990;45:587- 96.
12. Bircher AJ, Van Melle G, Haller E, et al. IgE to food allergens are highly prevalent in patients allergic to pollens, with and without symptoms of food allergy. Clin Exp Allergy 1994;24:367-74.
13. Breiteneder H, Ebner C. Molecular and biochemical classification of plant-derived food allergens. J All Clin Immunol 2000;106: 27-36.
14. Cambra O, Berrens L. Monoclonal antibodies against Dermatophagoides group I allergens as pseudo-cystatins blocking the catalytic site of cysteine proteinase. Immunol Lett 1996;50:173-7.
15. Daschner A, Crepe JF, Pascual CY. Specific IgE to recombinant vegetal panallergen (rBet v 2) and fruit allergy in pollinic patiens. Allergy 1998;53:614-8.
16. Eseverri JL, Botey J, Cozzo M, et al. Prevalence of allergy to latex in the pediatric population. Allergol Immunopathol 1999;27:133-40.
17. Anderson LBJ, Dreyeuss EM, Logan J, et al. Melon and banana sensitivity coincident with ragweed pollinosis. J Allergy 1970;45:310-9.
18. Hannuksela M, Laihti A. Immediate reactions to fruits and vegetables. Contact Dermatitis 1977;3:79-84.
19. Kremser M, Lindemayr W. Celery allergy (celery contact urticaria syndrome) and relation to allergies to other plant antigens. Wien Klim Wochenschr 1983;95:838-43.
20. M’raihi L, Charpin D, Pons A, et al. Crossreactivity between latex and banana. J All Clin Immunol 1991;87:129-30.
21. Reche M, Pascaul CY, Vicente J, et al. Tomato allergy in children and young adults: cross-reactivity with latex and potato. Allergy 2001;56:1197-201.
22. Sanchez-Monge R, Blanco C, Diaz-Perales A, et al. Isolation and characterizations of major banana allergens: identification as fruit class I chitinases. Clin Exp Allergy 1999;29: 673-80.
23. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J All Clin Immunol 1999;103:507-13.
24. Chen Z, Düser M, Flagge A, et al. Identification and characterization of cross-reactive natural rubber latex and Ficus benjamina allergens. Int Arch All Immunol 2000;123:291-8.
25. Yagami T, Sato M, Nakamura A, Komiyama T, et al. Plant defense - related enzymes as latex antigens. J All Clin Immunol 1998;101: 379-85.
26. Turjanmaa K, Alenius H, Makinen-Kiljunen S, Reunala T, Palosuo T. Natural rubber latex allergy. Allergy1996;51:593-602.
27. Posch A, Wheeler CH, Chen Z, et al. Class I endochitinase containing a hevein domain is the causative allergen in latex-associated avocado allergy. Clin Exp Allergy 1999;29:667-72.
28. Mikkola JH, Alenius H, Kalkkinen N, et al. Hevein-like protein domains as a possible cause for allergen cross-reactivity between latex and banana. J All Clin Immunol 1998;102: 1005-12.
29. Clendenne SK, May GD. Differential gene expression in ripening banana fruit. Plant Physiol 1997;115:463-9.
30. Blanco C, Carrillo T, Castillo R, et al. Latex allergy features and crossreactivity with fruits. Ann Allergy 1994;73:903-14.
31. Ortolani C, Ispano M, Pastorello E, et al. The oral allergy sindrome. Ann Allergy 1988; 61:47-52.
32. Sicherer SH. Clinical implications of allergy and clinical immunol. J Allergy Clin Immunol 2001;108:881-90.
33. Ballmer-Weber BK, Hoffmann A, Wüthrich B, et al. Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked in patients with celery allergy. Allergy 2000;57:228-35.
35. Pastorello EA, Prevettoni V, Farioli L, et al. Clinical role of a lipid transfer protein that acts as a new apple-specific allergen. J All Clin Immunol 1999;104:1099-106.
36. Sanchez-Monge R, Blanco C, Diaz-Perales A, et al. Isolation and characterization of major banana allergens: identification as fruit class I chitinases. Clin Exp Allergy 1999;29:673-80.
37. Pastorello EA, D’Ambrosio FP, Pravettoni V, et al. Evidence for a lipid tranfer protein as the major allergen of apricot. J All Clin Immunol 2000;105:371-77.
38. Pastorello EA, Pravettoni V, Farioli L, et al. Hypersensitivity to mugwort (Artemisia vulgaris) in patients with peach allergy is due to a common lipid tranfer protein allergen and is often without clinical expression. J All Clin Immunol 2002;110:310-17.
39. Curioni A, Santucci B, Cristaudo A, et al. Urticaria from beer: an immediate hypersensitivity reaction due to a 10-kDa protein derived from barley. Clin Exp Allergy 1999;29:407-13.
40. Gonzales R, Varela J, Carrera J, Polo F. Soybean hydrophobic protein and soybean hull allergy. Lancet 1995;346:48-9.
41. Valenta R, Duchene M, Ebner C, et al. Profilins constitute a novel family of functional plant pan-allergens. J Exp Med 1992;175:377-85.
42. Sanchez-Monge R, Blanco C, Diaz Perales A, et al. Class I chitinases, the panallergens responsible for the latex-fruit syndrome, are induced by ethylene treatment and inactivated by heating. J All Clin Immunol 2000;106:190-5.
43. Karamloo F, Wangorsch A, Kasahara H, et al. Phenylcoumaran benzylic ether and isoflavonoid reductases are a new class of crossreactive allergens in birch pollen, fruits and vegetables. Eur J Biochem 2001;268:5310-20.
44. Vieths S, Scheurer S, ballmer-Weber B. Current understanding of cross-reactivity of food allergens and pollen. Ann NY Acad Sci 2002;964:47-68.
45. Guiderdoni E, Cordero MJ, Vignols F, et al. Inducibility by pathogen attack and development regulation of the rice Ltp1 gene. Plant Mol Biol 2002;49:683-99.
46. Reindl J, Rihs HP, Scheurer S, et al. IgE reactivity to profiling in pollen-sensitized subjects with adverse reactions to banana and pineapple. Int Arch All Immunol 2002;128:105-14.
47. Kleber-Janke T, Crameri R, Appenzeller U, et al. Selective cloning of peanut allergens, including porfilin and 2S albumins, by phage display technology. Int Arch All Immunol 1999;119:265-74.
48. Ogawa T, Bando N, Tsuji H, et al. Alpha-subunit of beta-conglycinin, an allergenic protein recognized by IgE antibodies of soybean-sensitive patients with atopic dermatitis. Biosci Biotechnol Biochem 1995;59:831-3.
49. Collinge DB, Kragh KM, Mikkelsen JD, et al. Plant chitinases. Plant J 1993;3:31-40.
50. Grison R, Grezes-Besset B, Schneider M, et al. Field tolerance to fungal pathogens of Brassica napus constitutively expressing a chimeric chitinase gene. Nat Biotechnol 1996;4: 643-6.
51. Heil M, Bostock RM. Induced systemic resistance (ISR) against pathogens in the context of induced plant defences. Ann Bot (London) 2002;89:503-12.
52. O’Riordain G, Radauer K, Hoffmann-Sommergruber H, et al. Cloning and molecular characterization of the Hevea brasiliensis allergen Hevb11, a class I chitinase. Clin Exp Allergy 2002;32:455-62.
53. Yeh S, Moffatt BA, Griffith M, et al. Chitinase genes responsive to cold encode antifreeze proteins in winter cereals. Plant Physiol 2000;124:1251-64.
54. Hincha DK. Cryoprotectin: a plant lipidtransfer protein homologue that stabilizes membranes during freezing. Philos Trans R Soc Lond B Biol Sci 2002;357:909-16.
55. Franco OL, Rigden DJ, Melo FR, et al. Planta alpha-amylase inhibitors and their interaction with insect alpha-amylases. Eur J Biochem 2002;269:397-412.
56. Watanabe A, Nong VH, Zhang D, et al. Molecular cloning and ethylene-inducible expression of chib1 chitinase from soybean (Glycine max L.Merr.). Biosci Biotechnol Biochem 1999;63;251-6.
57. Taylor L, Hefle S. Will genetically modified foods be allergenic? J All Clin Immunol 2001;107:765-71.
2. Niestijl-Jansen J, Kardinaal AFM, Huijbers G, et al. Prevalence of food allergy and intolerance in the adult Dutch population. J All Clin Immunol 1994;93:446-56.
3. Bindslev-Jensen C. ABC of allergies Food Allergy. BMJ 1998; 516: 1299-302. 3a. ” Position Paper” EAACI pubblicata in Allergy 2001;9:813-24.
4. Sampson A. Use of food-challenge tests in children. Lancet 2001;358:1832-3.
5. May C. Objective clinical and laboratory studies of immediate hypersensibility reaction to food in asthmatic children. J All Clin Immunol 1976;58:500-15.
6. Caffarelli C, Petroccione T. False-negative food challenges in children with suspected food allergy. Lancet 2001;1:358:1871-2.
7. Jones SM, Mangolfi CF, Cooke SK, et al. Immunologic cross reactivity among cereals grains and grasses in children with food hypersensitivity. J All Clin Immunol 1995;96:341-51.
8. Rodriguez J, Crespo JF, Lopez-Rubio A, et al. Clinical cross reactivity among foods of the Rosaceae family. J All Clin Immunol 2000; 106:183-9.
9. Hill DJ, Hosking CS, Heine RG. Clinical spectrum of food allergy in children in Australia and South-East Asia: identification and targets for treatment. Ann Med 1999;31:272- 81.
10. Ishida T, Murai K, Yasuda T, et al. Oral allergy syndrome in patients with Japanese cedar pollinosis. Nippon Jibiinkoka Gakkai Kaiko 2000 Mar;103(3):199-205.
11. Host A, Halken S. A prospective study of cow milk allergy in Danish infants during the first three years of life: clinical course in relation to clinical and immunological type of hypersensitivity reaction. Allergy 1990;45:587- 96.
12. Bircher AJ, Van Melle G, Haller E, et al. IgE to food allergens are highly prevalent in patients allergic to pollens, with and without symptoms of food allergy. Clin Exp Allergy 1994;24:367-74.
13. Breiteneder H, Ebner C. Molecular and biochemical classification of plant-derived food allergens. J All Clin Immunol 2000;106: 27-36.
14. Cambra O, Berrens L. Monoclonal antibodies against Dermatophagoides group I allergens as pseudo-cystatins blocking the catalytic site of cysteine proteinase. Immunol Lett 1996;50:173-7.
15. Daschner A, Crepe JF, Pascual CY. Specific IgE to recombinant vegetal panallergen (rBet v 2) and fruit allergy in pollinic patiens. Allergy 1998;53:614-8.
16. Eseverri JL, Botey J, Cozzo M, et al. Prevalence of allergy to latex in the pediatric population. Allergol Immunopathol 1999;27:133-40.
17. Anderson LBJ, Dreyeuss EM, Logan J, et al. Melon and banana sensitivity coincident with ragweed pollinosis. J Allergy 1970;45:310-9.
18. Hannuksela M, Laihti A. Immediate reactions to fruits and vegetables. Contact Dermatitis 1977;3:79-84.
19. Kremser M, Lindemayr W. Celery allergy (celery contact urticaria syndrome) and relation to allergies to other plant antigens. Wien Klim Wochenschr 1983;95:838-43.
20. M’raihi L, Charpin D, Pons A, et al. Crossreactivity between latex and banana. J All Clin Immunol 1991;87:129-30.
21. Reche M, Pascaul CY, Vicente J, et al. Tomato allergy in children and young adults: cross-reactivity with latex and potato. Allergy 2001;56:1197-201.
22. Sanchez-Monge R, Blanco C, Diaz-Perales A, et al. Isolation and characterizations of major banana allergens: identification as fruit class I chitinases. Clin Exp Allergy 1999;29: 673-80.
23. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J All Clin Immunol 1999;103:507-13.
24. Chen Z, Düser M, Flagge A, et al. Identification and characterization of cross-reactive natural rubber latex and Ficus benjamina allergens. Int Arch All Immunol 2000;123:291-8.
25. Yagami T, Sato M, Nakamura A, Komiyama T, et al. Plant defense - related enzymes as latex antigens. J All Clin Immunol 1998;101: 379-85.
26. Turjanmaa K, Alenius H, Makinen-Kiljunen S, Reunala T, Palosuo T. Natural rubber latex allergy. Allergy1996;51:593-602.
27. Posch A, Wheeler CH, Chen Z, et al. Class I endochitinase containing a hevein domain is the causative allergen in latex-associated avocado allergy. Clin Exp Allergy 1999;29:667-72.
28. Mikkola JH, Alenius H, Kalkkinen N, et al. Hevein-like protein domains as a possible cause for allergen cross-reactivity between latex and banana. J All Clin Immunol 1998;102: 1005-12.
29. Clendenne SK, May GD. Differential gene expression in ripening banana fruit. Plant Physiol 1997;115:463-9.
30. Blanco C, Carrillo T, Castillo R, et al. Latex allergy features and crossreactivity with fruits. Ann Allergy 1994;73:903-14.
31. Ortolani C, Ispano M, Pastorello E, et al. The oral allergy sindrome. Ann Allergy 1988; 61:47-52.
32. Sicherer SH. Clinical implications of allergy and clinical immunol. J Allergy Clin Immunol 2001;108:881-90.
33. Ballmer-Weber BK, Hoffmann A, Wüthrich B, et al. Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked in patients with celery allergy. Allergy 2000;57:228-35.
35. Pastorello EA, Prevettoni V, Farioli L, et al. Clinical role of a lipid transfer protein that acts as a new apple-specific allergen. J All Clin Immunol 1999;104:1099-106.
36. Sanchez-Monge R, Blanco C, Diaz-Perales A, et al. Isolation and characterization of major banana allergens: identification as fruit class I chitinases. Clin Exp Allergy 1999;29:673-80.
37. Pastorello EA, D’Ambrosio FP, Pravettoni V, et al. Evidence for a lipid tranfer protein as the major allergen of apricot. J All Clin Immunol 2000;105:371-77.
38. Pastorello EA, Pravettoni V, Farioli L, et al. Hypersensitivity to mugwort (Artemisia vulgaris) in patients with peach allergy is due to a common lipid tranfer protein allergen and is often without clinical expression. J All Clin Immunol 2002;110:310-17.
39. Curioni A, Santucci B, Cristaudo A, et al. Urticaria from beer: an immediate hypersensitivity reaction due to a 10-kDa protein derived from barley. Clin Exp Allergy 1999;29:407-13.
40. Gonzales R, Varela J, Carrera J, Polo F. Soybean hydrophobic protein and soybean hull allergy. Lancet 1995;346:48-9.
41. Valenta R, Duchene M, Ebner C, et al. Profilins constitute a novel family of functional plant pan-allergens. J Exp Med 1992;175:377-85.
42. Sanchez-Monge R, Blanco C, Diaz Perales A, et al. Class I chitinases, the panallergens responsible for the latex-fruit syndrome, are induced by ethylene treatment and inactivated by heating. J All Clin Immunol 2000;106:190-5.
43. Karamloo F, Wangorsch A, Kasahara H, et al. Phenylcoumaran benzylic ether and isoflavonoid reductases are a new class of crossreactive allergens in birch pollen, fruits and vegetables. Eur J Biochem 2001;268:5310-20.
44. Vieths S, Scheurer S, ballmer-Weber B. Current understanding of cross-reactivity of food allergens and pollen. Ann NY Acad Sci 2002;964:47-68.
45. Guiderdoni E, Cordero MJ, Vignols F, et al. Inducibility by pathogen attack and development regulation of the rice Ltp1 gene. Plant Mol Biol 2002;49:683-99.
46. Reindl J, Rihs HP, Scheurer S, et al. IgE reactivity to profiling in pollen-sensitized subjects with adverse reactions to banana and pineapple. Int Arch All Immunol 2002;128:105-14.
47. Kleber-Janke T, Crameri R, Appenzeller U, et al. Selective cloning of peanut allergens, including porfilin and 2S albumins, by phage display technology. Int Arch All Immunol 1999;119:265-74.
48. Ogawa T, Bando N, Tsuji H, et al. Alpha-subunit of beta-conglycinin, an allergenic protein recognized by IgE antibodies of soybean-sensitive patients with atopic dermatitis. Biosci Biotechnol Biochem 1995;59:831-3.
49. Collinge DB, Kragh KM, Mikkelsen JD, et al. Plant chitinases. Plant J 1993;3:31-40.
50. Grison R, Grezes-Besset B, Schneider M, et al. Field tolerance to fungal pathogens of Brassica napus constitutively expressing a chimeric chitinase gene. Nat Biotechnol 1996;4: 643-6.
51. Heil M, Bostock RM. Induced systemic resistance (ISR) against pathogens in the context of induced plant defences. Ann Bot (London) 2002;89:503-12.
52. O’Riordain G, Radauer K, Hoffmann-Sommergruber H, et al. Cloning and molecular characterization of the Hevea brasiliensis allergen Hevb11, a class I chitinase. Clin Exp Allergy 2002;32:455-62.
53. Yeh S, Moffatt BA, Griffith M, et al. Chitinase genes responsive to cold encode antifreeze proteins in winter cereals. Plant Physiol 2000;124:1251-64.
54. Hincha DK. Cryoprotectin: a plant lipidtransfer protein homologue that stabilizes membranes during freezing. Philos Trans R Soc Lond B Biol Sci 2002;357:909-16.
55. Franco OL, Rigden DJ, Melo FR, et al. Planta alpha-amylase inhibitors and their interaction with insect alpha-amylases. Eur J Biochem 2002;269:397-412.
56. Watanabe A, Nong VH, Zhang D, et al. Molecular cloning and ethylene-inducible expression of chib1 chitinase from soybean (Glycine max L.Merr.). Biosci Biotechnol Biochem 1999;63;251-6.
57. Taylor L, Hefle S. Will genetically modified foods be allergenic? J All Clin Immunol 2001;107:765-71.