Problemi speciali
La linfopenia nel bambino
Lymphopoenia in children
Camilla Dallavilla, Raffaele Badolato
Clinica Pediatrica, Università di Brescia
Aprile 2015 - pagg. 239 -246
Abstract
Isolated lymphopoenia is a common finding in children evaluation. Usually, lymphopoenia
is observed in children with infectious or autoimmune diseases, with nutritional disorders
or under treatment with immunosuppressive drugs. However, persistence of low lymphocyte
counts, especially when associated with invasive or opportunistic infections,
eczema, diarrhoea, failure to thrive, lymphadenopathy or splenomegaly, should lead to
suspect lymphopoenia as manifestation of primary immunodeficiencies. In this context,
patients with lymphopoenia should be evaluated by analysis of serum immunoglobulins,
lymphocyte subpopulations and genetic studies. Secondary lymphopoenia is usually responsive
to the treatment of the primary disease, while idiopathic lymphopoenia will require
close clinical and laboratory monitoring and anti-microbial prophylaxis. Genetic diagnosis
is important to evaluate the clinical prognosis and develop specific treatment that
might include in selected case haematopoietic stem cell transplantation, or substitutive enzyme
therapy.
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Classificazione MeSH
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Bibliografia
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Corrispondenza: raffaele.badolato@unibs.i