Aggiornamento
L’esplorazione bioumorale del fegato: il bilancio epatico
BIOCHEMICAL EVALUATION OF LIVER FUNCTION
Giuseppe Maggiore
Unità di Gastroenterologia ed Epatologia, Dipartimento di Pediatria, Azienda Ospedaliera-Universitaria Pisana
Dicembre 2009 - pagg. 649 -653
Abstract
Liver function tests are a simple way to explore liver function and are a helpful tool to the
clinician to confirm the clinical suspect of liver disease. Practically, evaluation of liver
function includes determination of total and conjugated bilirubin as well as serum enzymes
by exploring the presence of hepatocellular or cholangiocellular damage such as aminotransferases,
alkaline phosphatase and gamma glutamyl transferase, and serum albumin
and protrombin activity which enable to determine synthetic liver activity. Total serum bile
acids concentration is useful in evaluating cholestatic liver disease and complete blood
cell count may give relevant information on the presence and progression of portal hypertension
by evaluating the reduction of leukocyte and platelets count related to hypersplenism.
Parole chiave
Suggerite dall'AI
Classificazione MeSH
Bibliografia
1. England, K, Thorne C, Pembrey L, Tovo,
PA, Newell ML. Age- and Sex-related Reference
Ranges of Alanine Aminotransferase
Levels in Children: European Paediatric
HCV Network. J Pediatr Gastroenterol Nutr
2009;49:71-7.
2. De Ritis F, Coltorti M, Giusti G. An enzymatic test for the diagnosis of viral hepatitis; the transaminasi serum activities. Clin Chim Acta 1957;2:70-4.
3. Tolentino P, Rossi M. Serum transaminase variations in childhood. Arch Dis Child 1958; 33:409-11.
4. Cohen GA, Goffinet JA, Donebedian RK, et al. Observation in decreased serum glutamic oxaloacetic transaminase activity in azotemic patients. Ann Inter Med 1976;84: 275.
5. Caropreso M, Fortunato G, Lenta S, et al. Prevalence and long-term course of macroaspartate aminotransferase in children. J Pediatr 2009;154:744-8.
6. Maggiore G, Bernard O, Riely CA, Hadchouel M, Lemonnier A, Alagille D. Normal serum gamma-glutamyl-transpeptidase activity identifies groups of infants with idiopathic cholestasis with poor prognosis. J Pediatr 1987;111:251-2.
2. De Ritis F, Coltorti M, Giusti G. An enzymatic test for the diagnosis of viral hepatitis; the transaminasi serum activities. Clin Chim Acta 1957;2:70-4.
3. Tolentino P, Rossi M. Serum transaminase variations in childhood. Arch Dis Child 1958; 33:409-11.
4. Cohen GA, Goffinet JA, Donebedian RK, et al. Observation in decreased serum glutamic oxaloacetic transaminase activity in azotemic patients. Ann Inter Med 1976;84: 275.
5. Caropreso M, Fortunato G, Lenta S, et al. Prevalence and long-term course of macroaspartate aminotransferase in children. J Pediatr 2009;154:744-8.
6. Maggiore G, Bernard O, Riely CA, Hadchouel M, Lemonnier A, Alagille D. Normal serum gamma-glutamyl-transpeptidase activity identifies groups of infants with idiopathic cholestasis with poor prognosis. J Pediatr 1987;111:251-2.
Corrispondenza: g.maggiore@clp.med.unipi.it