Splenomegaly

Quando l’anamnesi non aiuta... occhio alla clinica (e alla milza)

Sardella L, Abbagnato L, Agosti M, Salvatore S, Selicorni A.

2025/8 — pag. 530 — DOI

The case of a 15-year-old girl with Epstein-Barr virus infectious mononucleosis complicated by splenomegaly and traumatic splenic rupture with haemoperitoneum is described. She was treated with splenic embolization, blood transfusion, antibiotic ther...

Galeotto fu il parvovirus

Vecchi M, Cavalleri L

2025/8 — pag. 215-216 — DOI

A previously healthy 2.5-year-old child presented in critical condition with hypoglycemic coma, severe metabolic acidosis and profound anaemia. Diagnostic work-up revealed previously undiagnosed sickle cell disease (SCD) complicated by aplastic crisi...

Sclerosi epatoportale

Sparaventi C, Zago A, Di Leo G, Barbi E, Bramuzzo M.

2025/7 — pag. 453-455 — DOI

Hepatoportal sclerosis is a rare and underdiagnosed liver condition characterised by histological alterations of the portal venules and hepatic sinusoids, with periportal fibrosis and vascular narrowing. Its diagnosis is histological and requires liv...

Splenomegalia e malattia di Gaucher

Piccioni A, Santoro L, Bruschi B, Lionetti ME, Pugliese F

2025/7 — pag. 187-187 — DOI

A 4-year-old girl, asymptomatic and in good general health, is referred to a paediatric Haemato-Oncology centre for splenomegaly associated with mild anaemia and thrombocytopenia. Initial suspicion of leukaemia is ruled out after thorough clinical, l...

Trombocitopenia immune: quando le immunoglobuline non funzionano

Iannicelli A, Vorini MV, Beneduce G, Giagnuolo G, Parasole R, Menna G

2025/6 — pag. 162-163 — DOI

A 9-year-old boy was initially evaluated for macrocytic anaemia, neutrophilic leukocytosis and thrombocytopenia, with spontaneous ecchymoses but with no significant medical history. After ten months of follow-up, hematologic worsening occurred alongs...

Wilson Wilson Wilson

Carciofi A, Pugliese F, D'alba I, Coccia P, Lionetti ME, Gatti S

2025/5 — pag. 120-121 — DOI

A 13-year-old boy was admitted with abdominal pain, vomiting and unexplained cytopoenia. Initial investigations showed splenomegaly, ileal wall thickening, hepatic structural alterations and persistent pancytopenia. Extensive infectious, haematologic...

Leishmania e linfoistiocitosi emofagocitica (HLH)

Bratta A, Arcuri L, Micalizzi C

2025/2 — pag. 51-52 — DOI

Haemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening hyperinflammatory syndrome. The paper reports the case of a 5-month-old infant hospitalised with persistent fever, splenomegaly and significant inflammatory activation. After an ini...

Colecistite acuta da EBV

Favaretto E

2025/1 — pag. 21-22 — DOI

The paper describes a rare instance of acute acalculous cholecystitis (ACC) in a 7-year-old boy caused by Epstein-Barr virus (EBV) infection. Initially, he was suspected to have appendicitis, but subsequently imaging and laboratory tests revealed ACC...

Sferocitosi: una famiglia... tre malattie!

Ferrara D, Giordano C, Borsellino Z, Cuccia L, Ruffo GB, Corsello G.

2024/1 — pag. 54-57 — DOI

The paper describes the cases of three siblings affected by Hereditary Spherocytosis (HS). The different clinical presentations in the same family are examples of the heterogeneity of this pathology. HS is a common inherited type of haemolytic anaemi...

Quando pensare alla splenectomia in presenza di Beta-talassemia con drepanocitosi?

Stera G, Legnani E, Grasso A

2024/1 — pag. 21-21 — DOI

The authors describe the positive effect of splenectomy in two brothers affected by micro-drepanocytosis....

Sferocitosi: una famiglia... tre malattie!

Ferrara D, Giordano C, Borsellino Z, Cuccia L, Ruffo GB, Corsello G

2024/1 — pag. 5-8 — DOI

The paper describes the cases of three siblings affected by Hereditary Spherocytosis (HS). The different clinical presentations in the same family are examples of the heterogeneity of this pathology. HS is a common inherited type of haemolytic anaemi...

La solita anemia sideropenica non responsiva

Talloa D

2023/3 — pag. 54-54 — DOI

The author describes the case of a 15-year-old girl presenting with unresponsive iron deficiency anaemia and splenomegaly finally diagnosed as Gaucher’s disease....

Il tifo

Palladino F, Coppola C, Prisco A, Puzone S, Imperatore A, Brienza C, Nunziata F

2022/3 — pag. 68-70 — DOI

The paper describes the case of a 13-year-old boy presenting with fever with chills, abdominal pain and diarrhoea. Further investigation showed an “enteric fever”. Finally, clinical onset, diagnosis and disease management are discussed. ...

Quando la linfoistiocitosi emofagocitica è secondaria

Ventresca S, Fabbri E, Bracaglia C, Gasperini P, Filippini B, Libertucci F, Bigucci B, Pericoli R, Vergine G.

2022/2 — pag. 97-102 — DOI

The paper describes the case of a 1-year-old Caucasian boy with a 1-month history of fever and splenomegaly. Laboratory findings showed pancytopenia, hypertriglyceridemia and hyperferritinemia. Secondary haemophagocytic lymphohistiocytosis was suspec...

Quando non trascurare la splenomegalia nel lattante

Zama D, Parladori R, Muratore E, Melchionda F, Baronio F, Pession A

2021/8 — pag. 501-507 — DOI

Splenomegaly in children is really common and its main cause is infectious disease. The aetiology in newborns and older children is well established, while it is less defined in suckling infants. The paper describes three cases of splenomegaly in inf...

Ematemesi rivelatrice

R. Pillon

2019/8 — pag. 207-207

Troppo stanca troppo presto: la leucemia mielomonocitica giovanile

S. Contorno

2019/4 — pag. 95-95

Manifestazioni dell’infezione da virus di Epstein-Barr nel paziente con immunodeficit

F. Zunica, F. Saettini, A. Biondi, R. Badolato

2019/3 — pag. 163-169

Recurrent respiratory infections are frequent in healthy children. The association with peculiar signs and symptoms such as splenomegaly, lymphopenia, and hypogammaglobulinemia should induce suspicion of primary immunodeficiency (PID). The describe...

Le molte facce della istiocitosi a cellule di Langerhans

L. Picciano, R. Mancusi, M.C. Fedele, F. Palladino

2019/3 — pag. 52-52

Un’emolisi ben mascherata

G. Del Borrello

2018/6

Chronic haemolytic anaemia is a pathophysiological process that can be the expression of many possible etiologies (e.g. a congenital defect of a membrane protein, immune-mediated destruction, enzymopathies, altered erythrocyte development). The paper...

L’anemia che fa male

A. Bonadies, G. Rispoli

2017/7 — pag. 465-466

L’anemia che fa male

A. Bonadies, G. Rispoli

2017/7

Ipereosinofilia severa: un caso da non dimenticare

E. Santi

2017/6

Un fenotipo ALPS e una diagnosi inaspettata... di malattia di Gaucher

A. Beccaria, A. Mariani

2017/6

Brucellosi: un raro caso di recidiva

M.C. Castiglione

2017/1

Una splenomegalia… per caso

T. Di Chio, E. Randazzo, G. Maggiore

2016/4

Una febbre alta e persistente con epatosplenomegalia e citopenia

L. de Seta, M.S. Sabatino, F. de Seta, P. Siani

2015/7 — pag. 431-441

The case described is that of an 11-year-old child presenting with high fever, pharyngotonsillar exudate, submandibular strangles and hepatosplenomegaly. The elevated number of VCA IgM antibodies led to a diagnosis of infectious mononucleosis. The ...

Quando la sferocitosi incontra il chirurgo

C. Bibalo

2015/6 — pag. 391-392

Summary Hereditary spherocytosis is a common inherited disorder that is characterized by anaemia, jaundice and splenomegaly. It is reported worldwide and is the most common inherited anaemia in individuals of northern European ancestry. Clinical ...

Quando la sferocitosi incontra il chirurgo

C. Bibalo

2015/6

Summary Hereditary spherocytosis is a common inherited disorder that is characterized by anaemia, jaundice and splenomegaly. It is reported worldwide and is the most common inherited anaemia in individuals of northern European ancestry. Clinical ...

Wandering spleen in età pediatrica

L. Radillo, M. Maschio, A. Taddio, S. Furlan, E. Barbi

2014/10 — pag. 659-662

Al di là dell’occhio!

G. Ferrara, E. Zanelli

2014/3

Linfoadenite monolaterale con milza "impallinata": quale diagnosi?

A. Zucchini, P. Ricciardelli, F. Marchetti

2014/1 — pag. 54-56

È proprio colpa del gattino?

S. Nider

2014/1

Linfoadenite monolaterale con milza “impallinata”: quale diagnosi?

A. Zucchini, P. Ricciardelli, F. Marchetti

2014/1

Tante visite, una diagnosi “by proxy”: ALPS, la sindrome linfoproliferativa autoimmune

L. Sirianni, M. Mancuso

2013/1

Autoimmune lymphoproliferative syndrome or ALPS is a genetic disease associated with anomalous apoptosis in lymphocytes, lymphoproliferation and autoimmune manifestations. Generally, it is possible to observe severe lymphadenopathy, hepatosplenomegal...

Leishmania: un parassita, molte infezioni

S. Virano, D. Le Serre, S. Garazzino, E. Silvestro, P.A. Tovo

2012/8

A 10-year-old child presented with persistent fever, relevant hepatosplenomegaly and pancytopenia. Abdominal US imaging, serology for most relevant pathogens and Leishmania, PCR for Parvovirus B19 and bone marrow sample were performed in order to...

Caverne

E. Ugolini, P. Fioretti

2012/4 — pag. 259-260

Milza contorsionista

G. Cozzi, M. Maschio, E. Barbi

2010/6

La splenomegalia

M. Rabusin, F. Patarino

2007/8 — pag. 493-499

The spleen in infants and children is involved in a wide variety of pathological conditions. Splenic disorders may be isolated like splenic cysts or, more frequently, due to multiorgan or systemic disease including hepatic diseases, malignancy, hemo...

Un caso di eritrofagocitosi secondaria a leishmaniosi nell’entroterra friulano

F. Minen, C. Oretti, F. Marchetti, G. Zanazzo, M. Maschio, D. Lizzi, A Ventura

2007/5 — pag. 325-327

The present report describes the case of a 2-year-old girl that lives in Northern Italy suffering from a one month lasting fever, pallor and hepatosplenomegaly. Serum testing showed pancytopenia, high levels of immunoglobulins, hypertriglyceridemia a...

Una strana epatite autoimmune

G. Maggiore

2007/5 — pag. 320

Una milza enorme...

Mario Furbetta, Stefanie Rempp

2007/4 — pag. 255-256

Una dattilite bilaterale simmetrica

M. Lazzerini

2004/2

Una dattilite bilaterale simmetrica

M. Lazzerini

2004/2

Una dattilite bilaterale simmetrica

M. Lazzerini

2004/2

Una dattilite bilaterale simmetrica

M. Lazzerini

2004/2

Una dattilite bilaterale simmetrica

M. Lazzerini

2004/2

Malaria: diagnosi tempestiva

2002/9 — pag. 606-606

Report of a malaria case (temperature, convulsions, anaemia, splenomegaly) back from a trip to Africa....

Malattia emolitica neonatale (MEN) da basso peso per l’età gestazionale (SGA) con anemia diseritropoietica congenita (CDA) tipo I

L. Lupi, C. Visone

2001/5 — pag. 331-331

Report of a case of Congenital Dyserythropoietic Anaemia (CDA) of type I, clinically expressed since the first day of life, with colostatic jaundice, macrocitic anaemia, splenomegaly. Retrospective analysis of 17 cases of CDA....

Ittero neonatale e malattia di Nieman-Pick tipo C

C. Martini

2000/10 — pag. 679-680

A case of early onset Nieman-Pick type C disease, with neonatal onset of mixed hyperbilirubinemia and increased aminotransferases, and later development of hypotonia and psychomotor delay, is reported. The congenital, functional and metabolic caus...

Le β-talassemie

1999/8

Una "mici" da micio

G. Maggiore

1999/8 — pag. 516

Una splenomegalia febbrile con neutropenia

C. Malorgio

1998/9

Una splenomegalia febbrile con neutropenia

P. Tamaro, C. Malorgio

1998/9 — pag. 581